CAJ | 학술논문

目的：探讨标准剂量瑞舒伐他汀与辛伐他汀在不稳定型心绞痛患者治疗中的临床疗效差异。方法：选取通过冠状动脉造影确诊为冠心病不稳定型心绞痛的80例患者，随机分为A组（口服瑞舒伐他汀片10 mg/d）40例，B组（口服辛伐他汀片40 mg/d）40例，治疗8周后比较两组心绞痛缓解有效率及调节血脂效果差异。结果：（1）A组患者心绞痛缓解总有效率（92.5%）高于B组（86.7%）（P<0.05）。（2）两组患者总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）均较治疗前显著降低（均P<0.05）；且A组患者TC和LDL-C值分别较B组降低（均P<0.05）。结论：瑞舒伐他汀治疗不稳定型心绞痛患者的临床效果优于辛伐他汀。
목적：탐토표준제량서서벌타정여신벌타정재불은정형심교통환자치료중적림상료효차이。방법：선취통과관상동맥조영학진위관심병불은정형심교통적80례환자，수궤분위A조（구복서서벌타정편10 mg/d）40례，B조（구복신벌타정편40 mg/d）40례，치료8주후비교량조심교통완해유효솔급조절혈지효과차이。결과：（1）A조환자심교통완해총유효솔（92.5%）고우B조（86.7%）（P<0.05）。（2）량조환자총담고순（TC）화저밀도지단백담고순（LDL-C）균교치료전현저강저（균P<0.05）；차A조환자TC화LDL-C치분별교B조강저（균P<0.05）。결론：서서벌타정치료불은정형심교통환자적림상효과우우신벌타정。
Objective:To investigate the diffent efficacy of standard dose Rosuvastatin and Sim-vastatin in patients with unstable angina pectoris. Methods:Chosed 80 patients with unstable angina pectoris diagnosed by coronary artery angiography in the affiliated hospital of Jianghan University from January 2011 to December 2012 and divided into A group(40 patients)and B group(40 pa-tients)in randomized controlled methods,A group taken Rosuvastatin 10mg once daily,B group tak-en Simvastatin 40mg once daily,to compare the remission rate of angina pectoris and the effect of blood-fat regulating after treatment of eight weeks. Results:(1)The Rosuvastatin group(92.5%)has higher total clinical remission rate than Simvastatin group(86. 7%)(P< 0.05).(2)The two groups have lower total cholesterol(TC)and low density lipoprotein cholesterin(LDL-C)than those before the treatment(P< 0.05). The Rosuvastatin group have higher reduction rate of TC and LDL-C than Simvastatin group(P< 0.05). Conclusion:Rosuvastatin is superior to Simvastatin in patients with unstable angina pectoris.