CAJ | 학술논문

目的：探讨中药益气活血方治疗脑缺血再灌注损伤致血管性痴呆小鼠的最佳时间。方法：利用反复结扎双侧颈总动脉方式建立缺血再灌注血管性痴呆小鼠模型，经不同时间窗的益气活血方治疗后，观察模型小鼠脑神经递质去甲肾上腺素（NE）、多巴胺（DA）、5-羟色胺（5-TH）的含量。结果：益气活血方即刻治疗组、3天后治疗组均可增加脑组织中去甲肾上腺素（ NE）、多巴胺（ DA）、5-羟色胺（5-TH）的含量，对缺血再灌注血管性痴呆小鼠有一定的保护作用，其中即刻治疗组疗效最佳。结论：中药益气活血方治疗血管性痴呆的最佳时间以即刻为最好，3天以内均可有一定的效果，在条件许可的情况下，应采取尽早治疗的原则。
목적：탐토중약익기활혈방치료뇌결혈재관주손상치혈관성치태소서적최가시간。방법：이용반복결찰쌍측경총동맥방식건립결혈재관주혈관성치태소서모형，경불동시간창적익기활혈방치료후，관찰모형소서뇌신경체질거갑신상선소（NE）、다파알（DA）、5-간색알（5-TH）적함량。결과：익기활혈방즉각치료조、3천후치료조균가증가뇌조직중거갑신상선소（ NE）、다파알（ DA）、5-간색알（5-TH）적함량，대결혈재관주혈관성치태소서유일정적보호작용，기중즉각치료조료효최가。결론：중약익기활혈방치료혈관성치태적최가시간이즉각위최호，3천이내균가유일정적효과，재조건허가적정황하，응채취진조치료적원칙。
Objective:to explore the best time in treatment of BN mice induced by brain ischemia-reperfusion injury with Chinese medicine:Yiqi Huoxue formula ( benefiting qi for activating blood circulation ) .Methods: ischemia-reperfusion-induced BN model mice were made by repeatedly ligating bilateral carotid arteries.Observe NE, DA and 5-TH contents in brain neurotransmitter of the mice by treatment with Yiqi Huoxue fumula at different time window.Results:3 days'treatment could increase the NE , DA and 5-TH contents, which could protect the ischemia-reperfusion-induced BN model mice.The immediate treatment group responded the best.Conclusion:Yiqi Huoxue formula achieves the best result by immediate treatment to BN mice , effective within 3 days.If permitted, treating as early as possible is preferred.