河北医学
河北醫學
하북의학
HEBEI MEDICINE
2014年
7期
1142-1145
,共4页
尿毒症%血液透析%血液灌流%血液透析滤过%贫%血
尿毒癥%血液透析%血液灌流%血液透析濾過%貧%血
뇨독증%혈액투석%혈액관류%혈액투석려과%빈%혈
Uremic hemodalysis%Hemoperfusion%Hemodiafiltration%Parathyroid hormone%Anemia
目的:探讨不同血液净化方式对维持性血液透析患者贫血的影响。方法:选取2010年1月至2012年12月在我院维持性血液透析的患者60例并随机分成三组: HD组20例,HP+HD组23例, HDF+HD17例;观察三组患者治疗6个月前后血色素变化;并对三组患者治疗前后血β2-MG、iPTH、CRP、ALB 、KT/V、 EPO用量等相关因素进行分析。结果:治疗后三组患者血色素明显提高,与治疗前相比差异显著(P<0.05)。 HP+HD、HD+HDF组治疗后血素色提高更明显,与HD组相比较差异显著( P<0.05), HP+HD与HD+HDF两组间比较差异无统计学意义。 HP+HD与HD+HDF两组患者β2-MG、iPTH、CRP治疗后明显降低,较治疗前差别有统计学意义(P<0.05),两组间上述指标下降幅度比较差异无统计学意义( P>0.05)。单纯HD组患者β2-MG、iPTH、CRP 治疗前后差别无统计学意义( P>0.05)。三组患者治疗前后KT/V、ALB无明显差异( P>0.05);三组患者在观察结束时EPO用量均有所减少,但三组间以及与入组时相比差别无统计学意义( P>0.05)。结论:HP+HD及HD+HDF能更好改善维持性血液透析患者贫血状态,其机制可能与二者有效的清除维持性血液透析患者体内的大、中分子毒素有关。
目的:探討不同血液淨化方式對維持性血液透析患者貧血的影響。方法:選取2010年1月至2012年12月在我院維持性血液透析的患者60例併隨機分成三組: HD組20例,HP+HD組23例, HDF+HD17例;觀察三組患者治療6箇月前後血色素變化;併對三組患者治療前後血β2-MG、iPTH、CRP、ALB 、KT/V、 EPO用量等相關因素進行分析。結果:治療後三組患者血色素明顯提高,與治療前相比差異顯著(P<0.05)。 HP+HD、HD+HDF組治療後血素色提高更明顯,與HD組相比較差異顯著( P<0.05), HP+HD與HD+HDF兩組間比較差異無統計學意義。 HP+HD與HD+HDF兩組患者β2-MG、iPTH、CRP治療後明顯降低,較治療前差彆有統計學意義(P<0.05),兩組間上述指標下降幅度比較差異無統計學意義( P>0.05)。單純HD組患者β2-MG、iPTH、CRP 治療前後差彆無統計學意義( P>0.05)。三組患者治療前後KT/V、ALB無明顯差異( P>0.05);三組患者在觀察結束時EPO用量均有所減少,但三組間以及與入組時相比差彆無統計學意義( P>0.05)。結論:HP+HD及HD+HDF能更好改善維持性血液透析患者貧血狀態,其機製可能與二者有效的清除維持性血液透析患者體內的大、中分子毒素有關。
목적:탐토불동혈액정화방식대유지성혈액투석환자빈혈적영향。방법:선취2010년1월지2012년12월재아원유지성혈액투석적환자60례병수궤분성삼조: HD조20례,HP+HD조23례, HDF+HD17례;관찰삼조환자치료6개월전후혈색소변화;병대삼조환자치료전후혈β2-MG、iPTH、CRP、ALB 、KT/V、 EPO용량등상관인소진행분석。결과:치료후삼조환자혈색소명현제고,여치료전상비차이현저(P<0.05)。 HP+HD、HD+HDF조치료후혈소색제고경명현,여HD조상비교차이현저( P<0.05), HP+HD여HD+HDF량조간비교차이무통계학의의。 HP+HD여HD+HDF량조환자β2-MG、iPTH、CRP치료후명현강저,교치료전차별유통계학의의(P<0.05),량조간상술지표하강폭도비교차이무통계학의의( P>0.05)。단순HD조환자β2-MG、iPTH、CRP 치료전후차별무통계학의의( P>0.05)。삼조환자치료전후KT/V、ALB무명현차이( P>0.05);삼조환자재관찰결속시EPO용량균유소감소,단삼조간이급여입조시상비차별무통계학의의( P>0.05)。결론:HP+HD급HD+HDF능경호개선유지성혈액투석환자빈혈상태,기궤제가능여이자유효적청제유지성혈액투석환자체내적대、중분자독소유관。
Objective:To investigate the influence of afferent blood purification methods on anemia of uremic patients .Method: A total of 60 patients on maintenance hemodialysis treated in our hospital from Jaunary 2010 to December 2012 were recruited .They were randomly assigned into 3 groups: hemodialysis group (HD) (n=20),hemodiafihration +hemodialysis group (HD+HDF) (n=17),and hemoperfusion +hemodialysis group ( HD+HP ) ( n=23 ) .Blood samples were taken for the assays of serum anemia before and after the treatment .The change of hemoglobin have been observed major for the patients in three groups after 6 months treatment.At the same time , the related factors have been analysed about β2-MG,iPTH, CRP,ALB ,KT/V,EPO etc.Result:After the treatment for 6 months ,Hemoglobin of the three groups was improved, there was significant difference than before treatment (P<0.05), Hemoglobin was improved more distinct in HD+HP and HD+HDF groups , there was significant difference compared with HD group ( P<0. 05).But there was no difference between HD+HP and HD+HDF.β2-MG,iPTH and CRP was lower in HD+HP and HD+HDF groups than those in HD groups .KT/V and ALB were no change in three groups prethera-py and post-treatment(P>0.05).Dosage of erythropoiebin were less before treatment than post treatment , but there was no remarkable difference in three groups patients (P>0.05).Conclusion: HD+HP and HD+HDF could had better effect than the HD group on improving effectively anemia ,It is probably relating to the clear-ance of β2-MG,iPTH and CRP etc .