CAJ | 학술논문

通过乙酰乙酸乙酯与间苯二胺反应制得4-甲基-7-氨基-2-喹啉酮（3），进一步与氨三乙酸反应制得新的喹啉酮酰胺衍生物5，其结构经红外、核磁氢谱、质谱等表征。5与La（NO3）3配位得到新的配合物6。元素分析、红外、质谱、热重-差热分析和摩尔电导等确定配合物6的分子式为[La（C16 H15 N3 O6） NO3]·4H2 O。荧光测试表明，化合物5与稀土金属La配位后，荧光发光强度明显增加，荧光区间变窄。此外，化合物5与不同浓度鲱鱼精DNA作用的荧光变化情况表明：化合物5与鲱鱼精DNA有较强的相互作用，荧光光谱变化明显；鲱鱼精DNA对化合物5有荧光增强作用，DNA浓度为4.02×10-6 mol/L时，增幅最大可达40％。实验结果表明，化合物5在DNA检测或疾病防治等方面有潜在的应用价值。
통과을선을산을지여간분이알반응제득4-갑기-7-안기-2-규람동（3），진일보여안삼을산반응제득신적규람동선알연생물5，기결구경홍외、핵자경보、질보등표정。5여La（NO3）3배위득도신적배합물6。원소분석、홍외、질보、열중-차열분석화마이전도등학정배합물6적분자식위[La（C16 H15 N3 O6） NO3]·4H2 O。형광측시표명，화합물5여희토금속La배위후，형광발광강도명현증가，형광구간변착。차외，화합물5여불동농도비어정DNA작용적형광변화정황표명：화합물5여비어정DNA유교강적상호작용，형광광보변화명현；비어정DNA대화합물5유형광증강작용，DNA농도위4.02×10-6 mol/L시，증폭최대가체40％。실험결과표명，화합물5재DNA검측혹질병방치등방면유잠재적응용개치。
7-Amino-4-methyl-2 (1 H)-quinolinone was synthesized by the reaction of m-phenylenedia-mine with ethyl acetoacetate (3),which was further reacted with nitrilotriacetic acid and produced a new amide compound 5.The chemical structure of compound 5 was characterized by IR,1 H-NMR,and MS analyses.Coordination of compound 5 with La (NO3 )3 produced a new La complex 6 with a molecular formula of [La(C16H15N3O6)NO3]·4H2O,which was analyzed by IR,MS,TG-DTA,elemental analy-sis,and molar conductivity.The result of fluorescence analysis showed that the La-complex had a stron-ger fluorescence and narrower frequency-domain.The interaction of compound 5 with herring DNA solu-tion was also studied by fluorescent spectroscopy at different concentrations.An obvious change of the flu-orescent spectroscopy was observed,showing that there is a strong interaction between the DNA and com-pound 5.Addition of herring DNA could effectively enhance the luminescence intensity,and an intensity increased to 40% was observed at a DNA concentration of 4.02 ×10 -6 mol/L.Therefore,compound 5 has potential applications in DNA analysis and/or prevention and treatment of diseases.