中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2014年
2期
88-91
,共4页
刘洋%吕贝然%赵保胜%汪国鹏%韩晓燕%张雷%董红环%朱美玲%隗丽%唐明敏
劉洋%呂貝然%趙保勝%汪國鵬%韓曉燕%張雷%董紅環%硃美玲%隗麗%唐明敏
류양%려패연%조보성%왕국붕%한효연%장뢰%동홍배%주미령%외려%당명민
川芎%阿魏酸%溶出度%紫外分光光度法%威布尔模型
川芎%阿魏痠%溶齣度%紫外分光光度法%威佈爾模型
천궁%아위산%용출도%자외분광광도법%위포이모형
Chuanxiong%ferulic acid%dissolution%UV spectrophotometry%Weibull model
目的:比较川芎散剂在不同介质中的溶出度,探讨川芎散剂的溶出特征。方法采用桨法,以阿魏酸为指标,利用紫外分光光度法测定川芎散剂在5种介质(水、0.1 mol/L盐酸、pH 4.5醋酸缓冲盐、pH 6.8磷酸缓冲盐、pH 7.4磷酸缓冲盐)中的溶出量,绘制溶出曲线,以相似因子法和威布尔模型评价。结果川芎散剂在5种介质中的溶出量具有差异性。在水、0.1 mol/L盐酸、pH 4.5醋酸缓冲盐和pH 6.8磷酸缓冲盐中的溶出具有相似性且符合威布尔模型,在pH 7.4磷酸缓冲盐中的溶出则发生突变,30 min即达最大溶出量。结论川芎散剂在酸性到中性再到碱性介质中溶出量逐渐增多且溶出时间缩短,在酸性和中性介质中溶出曲线相似,在碱性介质中溶出快而完全。
目的:比較川芎散劑在不同介質中的溶齣度,探討川芎散劑的溶齣特徵。方法採用槳法,以阿魏痠為指標,利用紫外分光光度法測定川芎散劑在5種介質(水、0.1 mol/L鹽痠、pH 4.5醋痠緩遲鹽、pH 6.8燐痠緩遲鹽、pH 7.4燐痠緩遲鹽)中的溶齣量,繪製溶齣麯線,以相似因子法和威佈爾模型評價。結果川芎散劑在5種介質中的溶齣量具有差異性。在水、0.1 mol/L鹽痠、pH 4.5醋痠緩遲鹽和pH 6.8燐痠緩遲鹽中的溶齣具有相似性且符閤威佈爾模型,在pH 7.4燐痠緩遲鹽中的溶齣則髮生突變,30 min即達最大溶齣量。結論川芎散劑在痠性到中性再到堿性介質中溶齣量逐漸增多且溶齣時間縮短,在痠性和中性介質中溶齣麯線相似,在堿性介質中溶齣快而完全。
목적:비교천궁산제재불동개질중적용출도,탐토천궁산제적용출특정。방법채용장법,이아위산위지표,이용자외분광광도법측정천궁산제재5충개질(수、0.1 mol/L염산、pH 4.5작산완충염、pH 6.8린산완충염、pH 7.4린산완충염)중적용출량,회제용출곡선,이상사인자법화위포이모형평개。결과천궁산제재5충개질중적용출량구유차이성。재수、0.1 mol/L염산、pH 4.5작산완충염화pH 6.8린산완충염중적용출구유상사성차부합위포이모형,재pH 7.4린산완충염중적용출칙발생돌변,30 min즉체최대용출량。결론천궁산제재산성도중성재도감성개질중용출량축점증다차용출시간축단,재산성화중성개질중용출곡선상사,재감성개질중용출쾌이완전。
Objective To compare the dissolution of Chuangxiong powder in different medium and discuss the dissolution characteristics in vitro of Changxiong powder. Methods The paddle method was adopted, the UV spectrophotometric method was developed to determine the in vitro dissolution quantity of Changxiong powder in five medium (water, 0.1 mol/L hydrochloric acid, acetate buffer of pH 4.5, phosphate buffer of pH 6.8, phosphate buffer of pH 7.4) with ferulic acid as index, and evaluated by drawing the dissolution curve and using the similar factor method and Weibull model. Results The dissolution quantity of Changxiong oral powder in five medium was different. The dissolution quantity in water, 0.1 mol/L hydrochloric acid, acetate buffer of pH 4.5 and phosphate buffer of pH 6.8 was similar and fit Weibull model, but it mutated in phosphate buffer of pH 7.4 and reached the maximum amount at 30 min. Conclusion The dissolution quantity of Changxiong powder is gradually increasing and the time is shorted in the medium from acidic to neutral then to alkaline. Dissolution curve is similar in the acidic and neutral medium. Changxiong powder dissolves out fast and completely in the alkaline medium.