中国保健营养（中旬刊）
中國保健營養（中旬刊）
중국보건영양（중순간）
China Hwalth Care & nutrition
2013年
8期
605-605
,共1页
小肠间质瘤%免疫组化%诊断
小腸間質瘤%免疫組化%診斷
소장간질류%면역조화%진단
Smal intestinal stromal tumors%Immunohistochemistry%Diagnosis
目的：探讨小肠间质瘤的临床病理特点。方法：对22例小肠间质瘤临床资料综合分析，病理光镜检查，运用免疫组化检测 CD117、CD34、SMA、Ki-67。结果：22例小肠间质瘤患者平均年龄56岁，临床多以腹部不适、疼痛及腹部包块、肠梗阻而就诊。肿瘤平均直径3.5cm。免疫组化：CD117、CD34呈阳性表达，S-100、SMA 呈灶性或个别细胞阳性表达。光镜下见肿瘤由梭形细胞和上皮样细胞构成，形态与平滑肌瘤和神经鞘瘤难以鉴别。恶性间质瘤一般直径>4cm，核分裂>2个/50HPF，肿瘤呈浸润性生长，可见灶性出血坏死。结论：小肠间质瘤是小肠最常见的非上皮性肿瘤，可向多向分化。免疫组化检测 CD117、CD34是诊断本瘤的可靠依据。
目的：探討小腸間質瘤的臨床病理特點。方法：對22例小腸間質瘤臨床資料綜閤分析，病理光鏡檢查，運用免疫組化檢測 CD117、CD34、SMA、Ki-67。結果：22例小腸間質瘤患者平均年齡56歲，臨床多以腹部不適、疼痛及腹部包塊、腸梗阻而就診。腫瘤平均直徑3.5cm。免疫組化：CD117、CD34呈暘性錶達，S-100、SMA 呈竈性或箇彆細胞暘性錶達。光鏡下見腫瘤由梭形細胞和上皮樣細胞構成，形態與平滑肌瘤和神經鞘瘤難以鑒彆。噁性間質瘤一般直徑>4cm，覈分裂>2箇/50HPF，腫瘤呈浸潤性生長，可見竈性齣血壞死。結論：小腸間質瘤是小腸最常見的非上皮性腫瘤，可嚮多嚮分化。免疫組化檢測 CD117、CD34是診斷本瘤的可靠依據。
목적：탐토소장간질류적림상병리특점。방법：대22례소장간질류림상자료종합분석，병리광경검사，운용면역조화검측 CD117、CD34、SMA、Ki-67。결과：22례소장간질류환자평균년령56세，림상다이복부불괄、동통급복부포괴、장경조이취진。종류평균직경3.5cm。면역조화：CD117、CD34정양성표체，S-100、SMA 정조성혹개별세포양성표체。광경하견종류유사형세포화상피양세포구성，형태여평활기류화신경초류난이감별。악성간질류일반직경>4cm，핵분렬>2개/50HPF，종류정침윤성생장，가견조성출혈배사。결론：소장간질류시소장최상견적비상피성종류，가향다향분화。면역조화검측 CD117、CD34시진단본류적가고의거。
Objective : To investigate the clinicopathologic features of smal intestinal stromal tumors.Methods:Twenty-two cases of smal intestinal stromal tumors were analyzed by clinical data, optical microscopy, immunohistochemistry of CD117,CD34,S-100, SMA and ki-67.Results: Twenty-two cases of smal intestinal stromal tumors, the average age was 56;most of the patients presented with abdominal discomfort, enlarging abdominal mass often accompanied by variable abdominal pain, intestinal obstruction. The mean diameter of tumors was 3.5 cm. Immunohistochemical y, the tumor cells were positive for CD117, CD34, focal or individual cells expressed S-100, SMA. The tumor was composed of spindle and epithelioid cells. In morphology it was difficult to identify smal intestinal stromal tumors ,smooth muscle tumors and neurinoma. Malignant stromal tumor presented diameter >5 cm,>2/50HPF mitosis activity, infiltrative growth, focal hemorrhage and necrosis.Conclusion:Smal intestinal stromal tumor is the most common non-epithelial tumors of the smal intestine. It can show multiple differentiations. It was reliable diagnostic method by Immunohistochemical staining detection of CD117 and CD34.
