CAJ | 학술논문

目的：探讨肺部手术围手术期氨溴索的合适剂量。方法：选择在深圳市第二人民医院实施肺部手术的295例患者作为研究对象，分为对照组和A、B、C、D 治疗组，每组各59例。 A、B、C、D组术后分别使用30、60、90、120 mg盐酸氨溴索，对照组使用生理盐水100 mL。比较各组术后排痰情况、并发症发生率及抗生素使用时间。结果：治疗组治愈率、好转率高于对照组(P<0.05)；C、D组治愈率、好转率均高于A、B组(P<0.05)。对照组并发症发生率高于治疗；A、B组并发症发生率高于C、D组(P<0.05)。对照组抗生素使用时间长于治疗组(P<0.05)，A、B、C组抗生素使用时间长于D组(P<0.05)。结论：氨溴索可有效防止肺部手术围手术期的呼吸系统并发症，其临床剂量使用应适当偏用高剂量，具体最适剂量仍待进一步探索。
목적：탐토폐부수술위수술기안추색적합괄제량。방법：선택재심수시제이인민의원실시폐부수술적295례환자작위연구대상，분위대조조화A、B、C、D 치료조，매조각59례。 A、B、C、D조술후분별사용30、60、90、120 mg염산안추색，대조조사용생리염수100 mL。비교각조술후배담정황、병발증발생솔급항생소사용시간。결과：치료조치유솔、호전솔고우대조조(P<0.05)；C、D조치유솔、호전솔균고우A、B조(P<0.05)。대조조병발증발생솔고우치료；A、B조병발증발생솔고우C、D조(P<0.05)。대조조항생소사용시간장우치료조(P<0.05)，A、B、C조항생소사용시간장우D조(P<0.05)。결론：안추색가유효방지폐부수술위수술기적호흡계통병발증，기림상제량사용응괄당편용고제량，구체최괄제량잉대진일보탐색。
Objective:To investigate the appropriate perioperative dosing scheme for ambroxol in patients scheduled for lung surgery. Methods:We randomly allocated 295 patients who were scheduled for lung surgeries in Shenzhen Second People’ s Hospital to be treated with 100 mL natural saline intravenous injection ( control group, n=59), 30 mg ambroxol thrice daily (group A, n=59), 60 mg ambroxol thrice daily (group B, n=59), 90 mg ambroxol thrice daily (group C, n=59) and 120 mg ambroxol thrice daily (group D, n=59), respectively. We next compared the volume of sputum expectorated, the incidence of respiratory complications and the use of antibiotics. Results: Compared with control group, all treatment groups yielded a significantly higher rates of recovery and remission yet a lower incidence rate of complications (all P<0. 05). This held true for the comparisons between groups C and D, and between groups A and B (both P<0. 05). The control group was associated with a prolonged period of antibiotic use (all P<0. 05). Compared with groups A, B and C, a longer period of antibiotic use was noted in group D (all P<0. 05). Conclusions:Ambroxol effectively prevents from the incidence of perioperative respiratory complications. Despite that relatively high doses of ambroxol are recommended for clinical application, the optical doses merits further studies.