CAJ | 학술논문

目的：观察利培酮与氯氮平分别合并碳酸锂治疗有精神病性症状躁狂症的疗效及安全性。方法：将符合DSM-Ⅳ诊断标准的躁狂症患者60例，随机分为两组，在使用碳酸锂的同时，分别合并利培酮或氯氮平平进行为期8周的治疗。采用躁狂量表(BRMS)评定疗效，采用不良反应量表(TESS)评定不良反应。结果：利培酮与氯氮平平疗效相当，利培酮起效时间迟于氯氮平，但不良反应较轻，依从性好。结论：利培酮合并碳酸锂与氯氮平合并碳酸锂治疗躁狂症总体疗效相当，但安全性较高。
목적：관찰리배동여록담평분별합병탄산리치료유정신병성증상조광증적료효급안전성。방법：장부합DSM-Ⅳ진단표준적조광증환자60례，수궤분위량조，재사용탄산리적동시，분별합병리배동혹록담평평진행위기8주적치료。채용조광량표(BRMS)평정료효，채용불량반응량표(TESS)평정불량반응。결과：리배동여록담평평료효상당，리배동기효시간지우록담평，단불량반응교경，의종성호。결론：리배동합병탄산리여록담평합병탄산리치료조광증총체료효상당，단안전성교고。
Objective:To observe the effects of risperidone and clozapine both combined with lithium in treatment efficacy and safety of psychotic symptoms of mania.Methods:60 patients with mania were selected,all of them meet the DSM-Ⅳ diagnostic criteria on mania.They were randomly divided into 2 groups,at the same time of the use of lithium carbonate combined with risperidone or clozapine respectively,the treatment time is 8 weeks.The treatment efficacy assessed by Mania Rating Scale(BRMS), the adverse reactions assessed by side effects scale(TESS).Results:The treatment efficacy of risperidone and clozapine is equalized,the onset time of risperidone later than clozapine,but the adverse reaction of risperidone less than clozapine,and the former has better compliance.Conclusion:The efficacy of risperidone combine with lithium carbonate and clozapine combined with lithium in treatment of mania are equivalent,but risperidone has higher security.