中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2013年
11期
1636-1638
,共3页
呼吸窘迫综合征,成人%谷氨酰胺%药理学
呼吸窘迫綜閤徵,成人%穀氨酰胺%藥理學
호흡군박종합정,성인%곡안선알%약이학
Respiratory distress sydrome,adult%Glutamine%Pharmacology
目的 探讨谷氨酰胺对急性肺损伤肺部转归的影响.方法 将70例急性肺损伤患者根据数字表格法随机分为对照组和谷氨酰胺治疗组(Gln组),每组35例.两组均给予常规治疗和肠外营养支持,Gln组同时给予谷氨酰胺治疗.治疗7d,比较两组患者机械通气时间、重症监护室停留时间和治疗前后的APACHE Ⅱ评分、Murray肺损伤评分.结果 两组治疗后APACHE Ⅱ评分和Murray肺损伤评分较治疗前均明显改善(均P ＜0.05),其中Gln组治疗后APACHE Ⅱ评分和Murray肺损伤评分分别为(6.54±2.31)分和(0.53 ±0.42)分,均低于对照组治疗后的(10.43 ±2.15)分和(1.53±0.62)分(t=3.15、2.17,均P＜0.05).Gln组机械通气时间和重症监护室停留时间分别为(6.17 ±4.53)d、(13.41 ±8.74)d,均少于对照组的(11.57±5.25)d、(21.34±10.27)d(t=2.78、4.62,均P＜0.05).结论 谷氨酰胺有利于改善急性肺损伤患者的转归,是危重患者肠外营养的有效药物.
目的 探討穀氨酰胺對急性肺損傷肺部轉歸的影響.方法 將70例急性肺損傷患者根據數字錶格法隨機分為對照組和穀氨酰胺治療組(Gln組),每組35例.兩組均給予常規治療和腸外營養支持,Gln組同時給予穀氨酰胺治療.治療7d,比較兩組患者機械通氣時間、重癥鑑護室停留時間和治療前後的APACHE Ⅱ評分、Murray肺損傷評分.結果 兩組治療後APACHE Ⅱ評分和Murray肺損傷評分較治療前均明顯改善(均P ＜0.05),其中Gln組治療後APACHE Ⅱ評分和Murray肺損傷評分分彆為(6.54±2.31)分和(0.53 ±0.42)分,均低于對照組治療後的(10.43 ±2.15)分和(1.53±0.62)分(t=3.15、2.17,均P＜0.05).Gln組機械通氣時間和重癥鑑護室停留時間分彆為(6.17 ±4.53)d、(13.41 ±8.74)d,均少于對照組的(11.57±5.25)d、(21.34±10.27)d(t=2.78、4.62,均P＜0.05).結論 穀氨酰胺有利于改善急性肺損傷患者的轉歸,是危重患者腸外營養的有效藥物.
목적 탐토곡안선알대급성폐손상폐부전귀적영향.방법 장70례급성폐손상환자근거수자표격법수궤분위대조조화곡안선알치료조(Gln조),매조35례.량조균급여상규치료화장외영양지지,Gln조동시급여곡안선알치료.치료7d,비교량조환자궤계통기시간、중증감호실정류시간화치료전후적APACHE Ⅱ평분、Murray폐손상평분.결과 량조치료후APACHE Ⅱ평분화Murray폐손상평분교치료전균명현개선(균P ＜0.05),기중Gln조치료후APACHE Ⅱ평분화Murray폐손상평분분별위(6.54±2.31)분화(0.53 ±0.42)분,균저우대조조치료후적(10.43 ±2.15)분화(1.53±0.62)분(t=3.15、2.17,균P＜0.05).Gln조궤계통기시간화중증감호실정류시간분별위(6.17 ±4.53)d、(13.41 ±8.74)d,균소우대조조적(11.57±5.25)d、(21.34±10.27)d(t=2.78、4.62,균P＜0.05).결론 곡안선알유리우개선급성폐손상환자적전귀,시위중환자장외영양적유효약물.
Objective To explore the influence of glutamine on the outcome of acute lung injury.Methods According to the digital table,70 patients with acute lung injury were randomly divided into the control group and glutamine treatment group(Gln group),35 cases in each group.After 7 days treatment,APACHE Ⅱ score Murray lung injury score,duration of mechanical ventilation and ICU stay time of the two groups were compared.Results After treatment,the APACHE Ⅱ score and the Murray lung injury score were also improved(all P ＜ 0.05).The APACHE Ⅱ score and the Murray lung injury score of the Gln group were (6.54 ± 2.31) points and (0.53 ±0.42) points,respectively,which were significantly lower than those of the control group [(10.43 ± 2.15) points and (1.53 ± 0.62)points] (t =3.15,2.17,all P ＜0.05).The duration of mechanical ventilation and ICU stay time of the Gln group were (6.17 ±4.53)d,(13.41 ± 8.74)d,respectively,which were significantly less than those of the control group [(11.57 ±5.25)d,(21.34 ±10.27)d] (t =2.78,4.62,all P＜0.05).Conclusion Glutamine treatment can improve the prognosis of patients with acute lung injury,and it is a parenteral nutrition drug for critically ill patients.
