CAJ | 학술논문

目的：探讨重组人促红细胞生成素（ rhEPO ）对于颅脑损伤患者血清脑红蛋白（ NGB ）、血红蛋白（HGB）表达的影响。方法：选取50例重症监护病房颅脑损伤的患者，分为rhEPO组（30例）和对照组（20例）。rhEPO组患者在常规治疗的基础上于入院后第3、6、9、12天皮下注射rhEPO（10000 IU/次）；对照组患者仅给予常规治疗。监测所有患者入院时、入院第4、7、10和14天血清NGB、HGB含量及急性生理学及慢性健康状况评分系统Ⅱ（ APACHE Ⅱ）评分的变化。结果：rhEPO 组患者血清 NGB 含量（ F组间＝9．979， P ＝0．013；F时间＝11．560，P＜0．001；F交互＝16．813，P＜0．001）、HGB含量（F组间＝23．260，P＜0．001；F时间＝22．340，P＜0．001；F交互＝6．903，P＜0．001）较对照组增高，APACHE Ⅱ分值（ F组间＝9．339，P＝0．016；F时间＝13．749，P＜0．001；F交互＝5．497，P＜0．001）较对照组下降。结论：rhEPO可促进颅脑损伤患者NGB、HGB的表达，降低APACHE Ⅱ评分，具有一定的神经保护作用。
목적：탐토중조인촉홍세포생성소（ rhEPO ）대우로뇌손상환자혈청뇌홍단백（ NGB ）、혈홍단백（HGB）표체적영향。방법：선취50례중증감호병방로뇌손상적환자，분위rhEPO조（30례）화대조조（20례）。rhEPO조환자재상규치료적기출상우입원후제3、6、9、12천피하주사rhEPO（10000 IU/차）；대조조환자부급여상규치료。감측소유환자입원시、입원제4、7、10화14천혈청NGB、HGB함량급급성생이학급만성건강상황평분계통Ⅱ（ APACHE Ⅱ）평분적변화。결과：rhEPO 조환자혈청 NGB 함량（ F조간＝9．979， P ＝0．013；F시간＝11．560，P＜0．001；F교호＝16．813，P＜0．001）、HGB함량（F조간＝23．260，P＜0．001；F시간＝22．340，P＜0．001；F교호＝6．903，P＜0．001）교대조조증고，APACHE Ⅱ분치（ F조간＝9．339，P＝0．016；F시간＝13．749，P＜0．001；F교호＝5．497，P＜0．001）교대조조하강。결론：rhEPO가촉진로뇌손상환자NGB、HGB적표체，강저APACHE Ⅱ평분，구유일정적신경보호작용。
Aim:To explore the influence of rhEPO on expressions of serum neuroglobin and hemoglobin in patients with craniocerebral injury .Methods:Fifty cases of ICU patients with craniocerebral injury were randomly divided into rhE -PO group(30 cases) and control group(20 cases).The rhEPO group was given rhEPO by subcutaneous injection at 10 000 IU each time besides conventional treatment when admitted to hospital , on the 3rd day, 6th day, 9th day,and 12th day. The control group was just given conventional treatment .The neuroglobin , hemoglobin , APACHE Ⅱ score of all the pa-tients were monitored when admitted to hospital , on the 4th day, 7th day, 10th day, 14th day.Results:The neuroglobin in the rhEPO group was higher than the control group ( Fgroup =9.979,P=0.013;Ftime =11.560,P<0.001;Finteraction =16.813,P<0.001);the hemoglobin in rhEPO group was higher than that in the control group (Fgroup=23.260,P<0.001;Ftime =22.340,P<0.001;Finteraction =6.903,P<0.001);the APACHEⅡscore in rhEPO group was lower than that in the control group(Fgroup =9.339,P=0.016;Ftime =13.749,P<0.001;Finteraction =5.497,P<0.001).Conclusion: Using rhEPO in patients with craniocerebral injury can promote the expressions of neuroglobin and hemoglobin , and decrease A-PACHE Ⅱscore,thus play a certain role of neuroprotection .