中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2014年
10期
1358-1360
,共3页
宫颈肿瘤/病理学%宫颈肿瘤/放射摄影术%体层摄影术,X线计算机%淋巴转移
宮頸腫瘤/病理學%宮頸腫瘤/放射攝影術%體層攝影術,X線計算機%淋巴轉移
궁경종류/병이학%궁경종류/방사섭영술%체층섭영술,X선계산궤%림파전이
Uterine cervical neoplasms/pathology%Uterine cervical neoplasms/radiography%Tomography,X-ray computed%Lymphatic metastasis
目的 探讨宫颈癌淋巴管密度与CT灌注参数和癌组织淋巴管生成之间的关系.方法 对42例宫颈癌患者进行CT灌注检查,测定肿瘤组织中D2-40标记的淋巴管密度(LVD)水平,分析宫颈癌有无淋巴结转移组之间CT灌注参数和LVD的差异.结果 宫颈癌淋巴结转移组血流量(BF)、血容量(BV)、强化峰值(PEI)均高于无淋巴结转移组(t=-2.206、-2.29、-2.336,P＜0.05),淋巴结转移组的强化峰值时间(TTP)值显著短于无淋巴结转移组(t=6.908,P＜0.01).D2-40标记的微淋巴管呈棕黄色环状,结构清晰.肿瘤病灶周边有大量微淋巴管增.宫颈癌有淋巴结转移组BF、BV、PEI与LVD呈正相关(r =0.65、0.56、0.61,P＜0.01),而无淋巴结转移组TTP与LVD呈负相关(r=-0.55,P＜0.01).结论 宫颈癌CT灌注成像及D2-40 LVD的参数有助于甄别淋巴结的转移,高LVD值与宫颈癌进展、转移发生密切相关,其参数预测淋巴结转移的风险和预后,对临床治疗转归具有指导意义.
目的 探討宮頸癌淋巴管密度與CT灌註參數和癌組織淋巴管生成之間的關繫.方法 對42例宮頸癌患者進行CT灌註檢查,測定腫瘤組織中D2-40標記的淋巴管密度(LVD)水平,分析宮頸癌有無淋巴結轉移組之間CT灌註參數和LVD的差異.結果 宮頸癌淋巴結轉移組血流量(BF)、血容量(BV)、彊化峰值(PEI)均高于無淋巴結轉移組(t=-2.206、-2.29、-2.336,P＜0.05),淋巴結轉移組的彊化峰值時間(TTP)值顯著短于無淋巴結轉移組(t=6.908,P＜0.01).D2-40標記的微淋巴管呈棕黃色環狀,結構清晰.腫瘤病竈週邊有大量微淋巴管增.宮頸癌有淋巴結轉移組BF、BV、PEI與LVD呈正相關(r =0.65、0.56、0.61,P＜0.01),而無淋巴結轉移組TTP與LVD呈負相關(r=-0.55,P＜0.01).結論 宮頸癌CT灌註成像及D2-40 LVD的參數有助于甄彆淋巴結的轉移,高LVD值與宮頸癌進展、轉移髮生密切相關,其參數預測淋巴結轉移的風險和預後,對臨床治療轉歸具有指導意義.
목적 탐토궁경암림파관밀도여CT관주삼수화암조직림파관생성지간적관계.방법 대42례궁경암환자진행CT관주검사,측정종류조직중D2-40표기적림파관밀도(LVD)수평,분석궁경암유무림파결전이조지간CT관주삼수화LVD적차이.결과 궁경암림파결전이조혈류량(BF)、혈용량(BV)、강화봉치(PEI)균고우무림파결전이조(t=-2.206、-2.29、-2.336,P＜0.05),림파결전이조적강화봉치시간(TTP)치현저단우무림파결전이조(t=6.908,P＜0.01).D2-40표기적미림파관정종황색배상,결구청석.종류병조주변유대량미림파관증.궁경암유림파결전이조BF、BV、PEI여LVD정정상관(r =0.65、0.56、0.61,P＜0.01),이무림파결전이조TTP여LVD정부상관(r=-0.55,P＜0.01).결론 궁경암CT관주성상급D2-40 LVD적삼수유조우견별림파결적전이,고LVD치여궁경암진전、전이발생밀절상관,기삼수예측림파결전이적풍험화예후,대림상치료전귀구유지도의의.
Objective To investigate the correlation between the characteristics of the computed tomography (CT) perfusion parameters and the expression of D2-40 with lymphatic vessel density (LVD) in cervical carcinomas.Methods A total of 42 patients with cervical carcinoma was divided into two groups with and without lymph node metastasis.Patients were evaluated with CT perfusion scan before operation.Monoclonal antibody D2-40 was used for immunohistochemistry to detect the LVD in the carcinoma tissue specimen.CT perfusion parameters and LVD of two groups were compared,and their relationship was analyzed.Results CT perfusion parameters including blood flow (BF),peak enhancement image (PEI),and blood volume (BV) in the lymph node metastasis group were significantly higher than those in the no lymph node metastasis group (t =-2.206,-2.29,-2.336,P ＜ 0.05).The time to peak (TTP) was significantly lower in the lymph node metastasis group than the no node metastasis group (t =6.908,P ＜ 0.01).The LVD in the lymph node metastasis group was significantly higher than the no lymph node metastasis group (t =-5.092,P ＜ 0.01).The CT perfusion parameters (BF,PEI,BV) and LVD of cervical carcinomas had a significantly positive correlation (r =0.65,0.56,0.61,P ＜ 0.01).The TTP and LVD had a significantly negative correlation(r =-0.55,P ＜ 0.01).Conclusions CT perfusion imaging and higher LVD help to diagnose the lymph node metastasis of a cervical carcinoma,and have important guidance role in the surgical options for cervical cancers.
