北京航空航天大学学报（社会科学版）浙江中西医结合杂志
北京航空航天大學學報（社會科學版）浙江中西醫結閤雜誌
북경항공항천대학학보（사회과학판）절강중서의결합잡지
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
2014年
3期
191-194
,共4页
大鼠%糖尿病%高脂血症%桑叶总黄酮%p22phox mRNA%血糖%血脂
大鼠%糖尿病%高脂血癥%桑葉總黃酮%p22phox mRNA%血糖%血脂
대서%당뇨병%고지혈증%상협총황동%p22phox mRNA%혈당%혈지
rats%diabetes%hyperlipidemia%flavonoids from mulberry leaves%p22phox mRNA%blood glucose%blood lipids
目的：探讨桑叶总黄酮（FML）对糖尿病高脂血症大鼠血糖、血脂和胸主动脉p22phox mRNA表达的影响。方法60只雄性SD大鼠随机分成空白组、模型组、FML低、中、高剂量组和西药组，每组10只，观察FML对大鼠血糖、血脂、胸主动脉p22phox mRNA表达的影响。结果与空白组比较，模型组大鼠血糖、血脂显著升高（P<0.01），胸主动脉p22phox mRNA表达明显上调（P<0.01）。与模型组比较，FML中、高剂量组及西药组大鼠血糖、血脂降低（P<0.05或P<0.01），FML中、高剂量组及西药组大鼠胸主动脉p22phox mRNA表达明显下调（P<0.05或P<0.01）。结论 FML显著降低糖尿病高脂血症大鼠血糖、血脂水平，其机制可能与FML下调大鼠胸主动脉p22phox mRNA表达，进而抑制NADPH氧化酶活化有关。
目的：探討桑葉總黃酮（FML）對糖尿病高脂血癥大鼠血糖、血脂和胸主動脈p22phox mRNA錶達的影響。方法60隻雄性SD大鼠隨機分成空白組、模型組、FML低、中、高劑量組和西藥組，每組10隻，觀察FML對大鼠血糖、血脂、胸主動脈p22phox mRNA錶達的影響。結果與空白組比較，模型組大鼠血糖、血脂顯著升高（P<0.01），胸主動脈p22phox mRNA錶達明顯上調（P<0.01）。與模型組比較，FML中、高劑量組及西藥組大鼠血糖、血脂降低（P<0.05或P<0.01），FML中、高劑量組及西藥組大鼠胸主動脈p22phox mRNA錶達明顯下調（P<0.05或P<0.01）。結論 FML顯著降低糖尿病高脂血癥大鼠血糖、血脂水平，其機製可能與FML下調大鼠胸主動脈p22phox mRNA錶達，進而抑製NADPH氧化酶活化有關。
목적：탐토상협총황동（FML）대당뇨병고지혈증대서혈당、혈지화흉주동맥p22phox mRNA표체적영향。방법60지웅성SD대서수궤분성공백조、모형조、FML저、중、고제량조화서약조，매조10지，관찰FML대대서혈당、혈지、흉주동맥p22phox mRNA표체적영향。결과여공백조비교，모형조대서혈당、혈지현저승고（P<0.01），흉주동맥p22phox mRNA표체명현상조（P<0.01）。여모형조비교，FML중、고제량조급서약조대서혈당、혈지강저（P<0.05혹P<0.01），FML중、고제량조급서약조대서흉주동맥p22phox mRNA표체명현하조（P<0.05혹P<0.01）。결론 FML현저강저당뇨병고지혈증대서혈당、혈지수평，기궤제가능여FML하조대서흉주동맥p22phox mRNA표체，진이억제NADPH양화매활화유관。
Objective To investigate the influence of total flavonoids from mulberry leaves (FML) on blood glu-cose, blood lipid and the expression of p22phox mRNA in thoracic aorta in rats with diabetes and hyperlipidemia. Methods Diabetes and hyperlipidemia rats were used in this study. Sixty SD male rats were randomly into blank group, model group, treatment groups (high, middle, low dose of FML and western medicine group), 10 in each group. The effect of FML on blood glucose, blood lipid and the expression of p22phox mRNA in thoracic aorta was observed. Results Blood glucose, blood lipid and the expression of p22phox mRNA in thoracic aorta in rats in model group were higher than those in blank group(P<0.01). Compared with model group, rats in middle and high dose of FML groups and western medicine group had lower blood glucose, blood lipid and decreased expression of p22phox mRNA in thoracic aorta (P<0.05 or P<0.01). Conclusion FML can inhibit levels of blood glucose and blood lipids in diabetes and hyperlipidemia rats. This effect may be due to decreasing the expression of p22phox mRNA in thoracic aorta and then the activation of NADPH oxidase.
