CAJ | 학술논문

目的：观察早期亚低温联合单唾液酸四己糖神经节苷脂治疗对新生儿缺血缺氧性脑病（H IE ）的临床疗效。方法：将90例 H IE患儿随机分为两组，对照组（45例）给予对症、支持治疗，观察组（45例）在对症、支持治疗基础上加用单唾液酸四己糖神经节苷脂联合早期亚低温治疗。观察两组患儿治疗前、后临床表现、新生儿神经行为评分（NB-NA）、CT表现等指标。结果：治疗后观察组与对照组相比较，患儿治疗前、后的心率恢复好于后者（P＜0．05）；治疗后NBNA评分，观察组明显高于对照组（P＜0．01）；观察组治疗后脑CT正常增多，异常减少。结论：早期亚低温联合神经节苷脂对新生儿HIE的疗效显著，值得临床推广。
목적：관찰조기아저온연합단타액산사기당신경절감지치료대신생인결혈결양성뇌병（H IE ）적림상료효。방법：장90례 H IE환인수궤분위량조，대조조（45례）급여대증、지지치료，관찰조（45례）재대증、지지치료기출상가용단타액산사기당신경절감지연합조기아저온치료。관찰량조환인치료전、후림상표현、신생인신경행위평분（NB-NA）、CT표현등지표。결과：치료후관찰조여대조조상비교，환인치료전、후적심솔회복호우후자（P＜0．05）；치료후NBNA평분，관찰조명현고우대조조（P＜0．01）；관찰조치료후뇌CT정상증다，이상감소。결론：조기아저온연합신경절감지대신생인HIE적료효현저，치득림상추엄。
Objective :To observe the curative effect on monosialoganglioside and early mild hypothermia in treatment of neonatal hypoxic-ischemic encephalopathy .Methods:90 cases of HIE were randomly divided into 2 groups:control group(n=45 ,treated with symptomatic treatment and supportive treatment )and the observation group(n=45 ,treated with symptomatic and supportive therapy and monosialoganglioside and early mild hypothermia ) .The clinical symp-toms and and the scores of neonatal behavioral neurological assessment (NBNA ) and CT performance of two groups were observed and compared .Results:The heart rate recovery of control group were significantly (P<0 .05) .Neonatal behavioral neurological assessment (NBNA) score and normal CT performance was higher in the observation group than that in the control group(P<0 .01) .Conclusion:The curative effect of treating HIE with monosialoganglioside and early mild hypothermia was obvious ,which was worthy clinical application .