CAJ | 학술논문

目的：探讨注射不同剂量的免疫球蛋白对重症肌无力患者的临床效果，为重症肌无力的临床治疗提供可借鉴的方法。方法：选择我院2011年5月至2013年6月收治的重症肌无力患者54例为研究对象，随机分为ACTH组、小剂量IgG组、大剂量IgG组。观察并比较三组患者的临床疗效、住院时间及呼吸机使用时间等。结果：大剂量IgG组治疗有效率高于ACTH组和小剂量IgG组（ P＜0．05）；ACTH组和小剂量IgG组治疗有效率无显著性差异（ P＞0．05）。大剂量IgG组患者的住院时间和呼吸机使用时间均少于ACTH组和小剂量IgG组（ P＜0．05）。结论：静脉注射大剂量免疫球蛋白对重症肌无力的治疗具有重要的意义，不但可以获得良好的临床疗效，而且缩短了患者的住院时间，值得临床推广采用。
목적：탐토주사불동제량적면역구단백대중증기무력환자적림상효과，위중증기무력적림상치료제공가차감적방법。방법：선택아원2011년5월지2013년6월수치적중증기무력환자54례위연구대상，수궤분위ACTH조、소제량IgG조、대제량IgG조。관찰병비교삼조환자적림상료효、주원시간급호흡궤사용시간등。결과：대제량IgG조치료유효솔고우ACTH조화소제량IgG조（ P＜0．05）；ACTH조화소제량IgG조치료유효솔무현저성차이（ P＞0．05）。대제량IgG조환자적주원시간화호흡궤사용시간균소우ACTH조화소제량IgG조（ P＜0．05）。결론：정맥주사대제량면역구단백대중증기무력적치료구유중요적의의，불단가이획득량호적림상료효，이차축단료환자적주원시간，치득림상추엄채용。
Objective:To explore the clinical effects of immunoglobulin on the treatment of myasthenia gravis when injecting with different doses in order to make some references to the clinical treatment of the dis -ease.Methods:54 patients with myasthenia gravis who were treated in our hospital from May 2011 to June 2013were selected and randomly divided into the ACTH group , the low-dosed group and the large-dosed group .Then the clinical efficacy , the hospitalization and the time of respiratory were observed and compared . Rseults:The rate of treatment efficacy in the large -dosed group was higher than those of the other two groups ( P<0.05 ) .There was no statistically significant difference between the ACTH group and the low -dosed group(P>0.05);The hospitalization and the time of respiratory of patients in the large-dosed immunoglobu-lin group were less than those of the other two groups ( P<0.05) .Conclusion:It indicats that the injection of large-dosed immunoglobulin on the treatment of myasthenia gravis should be well promoted for the clinical efficacy and less time for hospitalization .