河北医学
河北醫學
하북의학
HEBEI MEDICINE
2014年
5期
744-748
,共5页
瑞舒伐他汀%培哚普利%高密度脂蛋白与低密度脂蛋白比值%颈动脉内膜中层厚度
瑞舒伐他汀%培哚普利%高密度脂蛋白與低密度脂蛋白比值%頸動脈內膜中層厚度
서서벌타정%배타보리%고밀도지단백여저밀도지단백비치%경동맥내막중층후도
Rosuvastatin%Perindopril%LDL-C/HDL-C%Carotid intima media thickness
目的：探讨瑞舒伐他汀联合培哚普利对高血压患者低密度脂蛋白胆固醇（ LDL-C ）/高密度脂蛋白胆固醇（ HDL-C）和颈动脉内膜中层厚度（ IMT）的影响及二者之间的相关性。方法：入选初诊高血压伴高LDL-C血症患者126例，在给予基础降压治疗基础上随机分为治疗组63例（培哚普利＋瑞舒伐他汀治疗）和对照组63例（瑞舒伐他汀治疗）。比较治疗前和治疗3周后血压、LDL-C、HDL-C、LDL-C/HDL-C和IMT变化。结果：治疗后治疗组收缩压、舒张压和平均动脉压均较对照组下降明显（P＝0．012，P＝0．029，P＝0．037）。两组患者治疗前后LDL-C、HDL-C比较均没有统计学差异（P均＞0．05）。但治疗组治疗后LDL-C/HDL-C下降较对照组明显（P＝0．007），平均IMT和最大IMT均明显小于照组（ P＝0．001，P＜0．001）。治疗前后LDL-C/HDL-C差值与平均IMT差值呈正相关（ P＜0．001，r＝0．742）。结论：瑞舒伐他汀联合培哚普利可以逆转高血压伴高LDL-C血症患者颈动脉内膜斑块，二者联合使用对减少心脑血管疾病的发生有重要意义。
目的：探討瑞舒伐他汀聯閤培哚普利對高血壓患者低密度脂蛋白膽固醇（ LDL-C ）/高密度脂蛋白膽固醇（ HDL-C）和頸動脈內膜中層厚度（ IMT）的影響及二者之間的相關性。方法：入選初診高血壓伴高LDL-C血癥患者126例，在給予基礎降壓治療基礎上隨機分為治療組63例（培哚普利＋瑞舒伐他汀治療）和對照組63例（瑞舒伐他汀治療）。比較治療前和治療3週後血壓、LDL-C、HDL-C、LDL-C/HDL-C和IMT變化。結果：治療後治療組收縮壓、舒張壓和平均動脈壓均較對照組下降明顯（P＝0．012，P＝0．029，P＝0．037）。兩組患者治療前後LDL-C、HDL-C比較均沒有統計學差異（P均＞0．05）。但治療組治療後LDL-C/HDL-C下降較對照組明顯（P＝0．007），平均IMT和最大IMT均明顯小于照組（ P＝0．001，P＜0．001）。治療前後LDL-C/HDL-C差值與平均IMT差值呈正相關（ P＜0．001，r＝0．742）。結論：瑞舒伐他汀聯閤培哚普利可以逆轉高血壓伴高LDL-C血癥患者頸動脈內膜斑塊，二者聯閤使用對減少心腦血管疾病的髮生有重要意義。
목적：탐토서서벌타정연합배타보리대고혈압환자저밀도지단백담고순（ LDL-C ）/고밀도지단백담고순（ HDL-C）화경동맥내막중층후도（ IMT）적영향급이자지간적상관성。방법：입선초진고혈압반고LDL-C혈증환자126례，재급여기출강압치료기출상수궤분위치료조63례（배타보리＋서서벌타정치료）화대조조63례（서서벌타정치료）。비교치료전화치료3주후혈압、LDL-C、HDL-C、LDL-C/HDL-C화IMT변화。결과：치료후치료조수축압、서장압화평균동맥압균교대조조하강명현（P＝0．012，P＝0．029，P＝0．037）。량조환자치료전후LDL-C、HDL-C비교균몰유통계학차이（P균＞0．05）。단치료조치료후LDL-C/HDL-C하강교대조조명현（P＝0．007），평균IMT화최대IMT균명현소우조조（ P＝0．001，P＜0．001）。치료전후LDL-C/HDL-C차치여평균IMT차치정정상관（ P＜0．001，r＝0．742）。결론：서서벌타정연합배타보리가이역전고혈압반고LDL-C혈증환자경동맥내막반괴，이자연합사용대감소심뇌혈관질병적발생유중요의의。
Objective:To investigate the efficacy of rosuvastatin combined with perindopril on LDL-C/HDL-C and carotid intima media thickness ( IMT) in hypertension patients, and the correlation between LDL-C/HDL-C and IMT.Method:A total of 126 high LDL-C patients with newly diagnosed hypertension were randomized to treatment group (n=63) and control group (n=63) after enrolled.On the basis of rou-tine antihypertensive therapy , treatment group received rosuvastatin treatment with the addition of perindopril and control group received rosuvastatin treatment only .Blood pressure , LDL-C, HDL-C, LDL-C/HDL-C and IMT were collected before and after 3 weeks treatment .Result:Systolic blood pressure ( SBP ) , dystolic blood pressure ( DBP ) , and mean blood pressure in treatment group were lower than that in control group af-ter treatment (P=0.012, P=0.029, P=0.037).Blood levels of LDL-C and HDL-C were similar between the two groups ( all P>0.05) .But levels of LDL-C/HDL-C, mean IMT and MAX IMT in treatment group all decreased significantly after treatment compared to control group ( P=0.007, P=0.001, P<0.001). Changes of LDL-C/HDL-C was positively correlated with changes of mean IMT (P<0.001,r=0.742).Con-clusion:Rosuvastatin combined with perindopril can reverse carotid intima atherosclerosis in hypertension patients with high LDL-C.Both of them are closely correlated with preventing cardiovascular and cerebrovas-cular diseases .
