CAJ | 학술논문

目的：探讨耐药基因P-gp、GST、ToPo-Ⅱ与bcl-2（凋亡基因）及p53（抑癌基因）在肺癌组织中表达及意义。方法：收集2010年1月至2012年4月间我科因肺癌行手术切除标本161份癌组织，采用免疫组化S-P法检测癌组织中P-gp、ToPo-Ⅱ、GST、bcl-2、p53的表达情况。结果：大细胞癌和腺鳞癌中P-gp、ToPo-Ⅱ、GST、bcl-2表达明显高于其它类型的非小细胞癌（ P＜0．05）；P-gp、ToPo-Ⅱ、GST、bcl-2阳性表达率与癌组织分化程度呈正相关，与p53呈负相关性； P-gp、GST、bcl-2表达阳性率均与p53具有相关性。结论： P-gp、ToPo-Ⅱ、GST、bcl-2、p53在肺癌多药耐药中起重要作用，联合检测有助于判断疗效及预后。
목적：탐토내약기인P-gp、GST、ToPo-Ⅱ여bcl-2（조망기인）급p53（억암기인）재폐암조직중표체급의의。방법：수집2010년1월지2012년4월간아과인폐암행수술절제표본161빈암조직，채용면역조화S-P법검측암조직중P-gp、ToPo-Ⅱ、GST、bcl-2、p53적표체정황。결과：대세포암화선린암중P-gp、ToPo-Ⅱ、GST、bcl-2표체명현고우기타류형적비소세포암（ P＜0．05）；P-gp、ToPo-Ⅱ、GST、bcl-2양성표체솔여암조직분화정도정정상관，여p53정부상관성； P-gp、GST、bcl-2표체양성솔균여p53구유상관성。결론： P-gp、ToPo-Ⅱ、GST、bcl-2、p53재폐암다약내약중기중요작용，연합검측유조우판단료효급예후。
Objective:To study the expression and significance of drug resistance gene P -gp, GST, ToPo-Ⅱand bcl-2 gene ( apoptosis gene ) and p53 ( anti-oncogene ) in lung cancer tissues .Method:A to-tal of 161 carcinoma tissue specimens collected from lung cancer patients surgically resected in our depart-ment from Jan.2010 to Apr.2012.Using immunohistochemical S-P method to detect the expression of P-gp, ToPo-Ⅱ, GST, bcl-2 and p53 in cancer tissue .Result:The expression of P-gp, ToPo-Ⅱ, GST and bcl-2 in the glands squamous carcinoma and large cell carcinoma is significantly higher than other types of non-small cell carcinoma (P<0.05); P-gp, ToPo-Ⅱ, GST and bcl-2 positive expression rate was posi-tively associated with the degree of differentiation in cancer tissue , and negatively correlation with p 53;posi-tive expression rate of P-gp, GST and bcl-2 were associated with p 53.Conclusion: P-gp, ToPo-Ⅱ, GST, bcl-2 and p53 play an important role in lung cancer on multi-drug resistance , the joint detection helps to judge the curative effect and prognosis .