CAJ | 학술논문

目的观察沙格雷酯治疗下肢血管病变的效果.方法 33名患者按2:1随机分配进入沙格雷酯治疗组(22例)和阿司匹林对照组(11例).沙格雷酯用量为300 mg/d,对照组口服阿司匹林100mg/d共3个月.比较两组治疗前后及其组间下肢血管病变、神经病变的症状、无痛行走距离、能耐受疼痛的最大行走距离和踝/肱血压指数(ABI).结果沙格雷酯治疗组增加最大行走和无痛行走距离,部分改善足背动脉和胫后动脉的流速、阻力指数和ABI指标.结论沙格雷酯治疗下肢血管病变,能有效增加患者最大行走距离、无痛行走距离,改善下肢供血.
목적 관찰사격뢰지치료하지혈관병변적효과.방법 33명환자안2:1수궤분배진입사격뢰지치료조(22례)화아사필림대조조(11례).사격뢰지용량위300 mg/d,대조조구복아사필림100mg/d공3개월.비교량조치료전후급기조간하지혈관병변、신경병변적증상、무통행주거리、능내수동통적최대행주거리화과/굉혈압지수(ABI).결과 사격뢰지치료조증가최대행주화무통행주거리,부분개선족배동맥화경후동맥적류속、조력지수화ABI지표.결론 사격뢰지치료하지혈관병변,능유효증가환자최대행주거리、무통행주거리,개선하지공혈.
Objective To study the effect of sarpogrelate hydrochloride(Anplag)treatment on the peripheral artery diseases(PAD)in the patients with type 2 diabetes.Methods Thirty-three diabetic patients with PAD were randomized into 2 groups.Anplag group(n=22,300 mg daily)and Aspirin(n=11,100 mgdaily)for 12 weeks.Both pain-free and maximal walking distance,ankle-branchial blood pressure index(ABI),and ultrasonic angiography image of the peripheral vessels were compared before and after the treatment between two groups.Results The pain-free and maximal walking distance,as well as blood perfusion of the peripheral arteries were increased after treatment.The difference was only significant in the Anplag group. No obvious side effects of Anplag were observed.Conclusion Anplag can be effectively and safely used in treating diabetic peripheral artery diseases.