内蒙古民族大学学报（自然科学版）
內矇古民族大學學報（自然科學版）
내몽고민족대학학보（자연과학판）
JOURNAL OF INNER MONGOLIA UNIVERSITY FOR NATIONALITIES(NATURAL SCIENCES)
2014年
1期
74-76
,共3页
蒙药加减通拉嘎-5%骨质疏松症%维甲酸
矇藥加減通拉嘎-5%骨質疏鬆癥%維甲痠
몽약가감통랍알-5%골질소송증%유갑산
Mongolian medicine Plusminus Tonglaga-5%Osteoporosis%Retinoic acid
目的：观察蒙药加减通拉嘎-5对维甲酸所致大鼠骨质疏松的治疗作用。方法：雌性Wistar大鼠32只，随机分为空白组，模型组，骨肽片组，加减通拉嘎-5组，采用维甲酸诱导大鼠骨质疏松的模型，观察经蒙药加减通拉嘎-5治疗前后大鼠血清中钙（Ca）、磷（P）、血清碱性磷酸酶（ALP）及脏器指数、骨组织形态计量学的变化。结果：与模型组比较，经蒙药加减通拉嘎-5治疗后，维甲酸所致骨质疏松大鼠骨组织形态计量学参数变化均有显著性差异，血清中碱性磷酸酶显著降低，钙、磷含量升高，结论：蒙药加减通拉嘎-5对维甲酸诱导的大鼠骨质疏松有一定的治疗作用。
目的：觀察矇藥加減通拉嘎-5對維甲痠所緻大鼠骨質疏鬆的治療作用。方法：雌性Wistar大鼠32隻，隨機分為空白組，模型組，骨肽片組，加減通拉嘎-5組，採用維甲痠誘導大鼠骨質疏鬆的模型，觀察經矇藥加減通拉嘎-5治療前後大鼠血清中鈣（Ca）、燐（P）、血清堿性燐痠酶（ALP）及髒器指數、骨組織形態計量學的變化。結果：與模型組比較，經矇藥加減通拉嘎-5治療後，維甲痠所緻骨質疏鬆大鼠骨組織形態計量學參數變化均有顯著性差異，血清中堿性燐痠酶顯著降低，鈣、燐含量升高，結論：矇藥加減通拉嘎-5對維甲痠誘導的大鼠骨質疏鬆有一定的治療作用。
목적：관찰몽약가감통랍알-5대유갑산소치대서골질소송적치료작용。방법：자성Wistar대서32지，수궤분위공백조，모형조，골태편조，가감통랍알-5조，채용유갑산유도대서골질소송적모형，관찰경몽약가감통랍알-5치료전후대서혈청중개（Ca）、린（P）、혈청감성린산매（ALP）급장기지수、골조직형태계량학적변화。결과：여모형조비교，경몽약가감통랍알-5치료후，유갑산소치골질소송대서골조직형태계량학삼수변화균유현저성차이，혈청중감성린산매현저강저，개、린함량승고，결론：몽약가감통랍알-5대유갑산유도적대서골질소송유일정적치료작용。
Objective:To investigate the therapeutical effect of Mongolian medicine Plusminus Tonglaga-5 on osteopo-rosis rats induced by retinoic acid. Methods:32 female Wistar rats were randomly divided into control group, model group, Ossotide Tablets group, Plusminus Tonglaga-5 group, 8 rats in each group. The osteoporosis rat model was es-tablished by retinoic acid. The changes of serum calcium(Ca), phosphorus(P), serum alkaline phosphatase(ALP), organ index, bone histomorphometry before and after treating with Plusminus Tonglaga-5 were observed and compared. Results:Compared with the model group, the changes of bone histomorphometry parameters in the Plusminus Tongla-ga-5 group had significant differences, the serum alkaline phosphatase decreased significantly, the serum calcium and phosphorus content increased. Conclusion:Mongolian medicine Plusminus Tonglaga-5 has a therapeutic effect on ret-inoic acid-induced osteoporosis in rats.
