CAJ | 학술논문

目的：观察异丙酚静脉全麻诱导用于腹腔镜胆囊切除术的术中知晓及遗忘作用。方法：将221例行腹腔镜胆囊切除术的患者随机分为实验组(114例)和对照组(107例)，分别采用异丙酚2 mg/kg及依托咪酯0.4 mg/kg诱导麻醉。术后48 h内双盲法获取麻醉中知晓及遗忘作用结果。结果：实验组离室时间明显短于对照组(P<0.0l)，离室时未清醒病例明显少于对照组(P<0.05)。实验组术中知晓率明显大于对照组(P<0.05)；知晓病例麻醉深度、无痛知晓率少于对照组(P<0.05)；下台搬动知晓、离室指令知晓、离室时清醒病例均高于对照组(P<0.05)。结论：异丙酚诱导麻醉术后清醒快，知晓发生率高；依托咪酯诱导麻醉离室时间长于异丙酚，但知晓发生率低，遗忘作用强。
목적：관찰이병분정맥전마유도용우복강경담낭절제술적술중지효급유망작용。방법：장221례행복강경담낭절제술적환자수궤분위실험조(114례)화대조조(107례)，분별채용이병분2 mg/kg급의탁미지0.4 mg/kg유도마취。술후48 h내쌍맹법획취마취중지효급유망작용결과。결과：실험조리실시간명현단우대조조(P<0.0l)，리실시미청성병례명현소우대조조(P<0.05)。실험조술중지효솔명현대우대조조(P<0.05)；지효병례마취심도、무통지효솔소우대조조(P<0.05)；하태반동지효、리실지령지효、리실시청성병례균고우대조조(P<0.05)。결론：이병분유도마취술후청성쾌，지효발생솔고；의탁미지유도마취리실시간장우이병분，단지효발생솔저，유망작용강。
Objective:To evaluate the effects of propofol on awareness and forgetfulness in patients receiving laparoscopic cholecystectomy. Methods: We randomly allocated 221 patients who underwent laparoscopic cholecystectomy to be treated with 2mg/kg propofol ( experimental group) and 0. 4 mg/kg etomidate ( control group) for induction of anesthesia. Awareness and forgetfulness were evaluated within 48 hours postoperatively, in a double-blind fashion. Results:The experimental group was associated with a markedly reduced length to be discharged and proportion of patients remaining unconscious upon discharge from the operation room, a greater consciousness rate during the operation and lower consciousness rates of the magnitude of anesthesia and pain ( all P<0. 05). In addition, higher awareness rates of using ambulatory beds, commands from the medical staffs and consciousness upon discharge from the operation room were found in experimental group (all P < 0. 05). Conclusion:Propofol-induced anesthesia is characterized by rapid courses of resuming consciousness and a high awareness rate postoperatively, whilst etomidate-induced anesthesia is related to a longer duration of action and lower rates of consciousness indicating significant capacity of inducing forgetfulness in patients who receives laparoscopic cholecystectomy.