CAJ | 학술논문

目的：探讨重组人血管内皮抑制素注射液（恩度）联合FOLFIRI方案治疗晚期大肠癌的疗效和不良反应。方法对40例初治或复治晚期大肠癌患者采用恩度联合FOLFIRI方案治疗，2周期后评价疗效。结果40例患者共完成80周期治疗，可评价疗效及不良反应，总有效率为39.1％，不良反应主要表现为骨髓抑制白细胞减少、恶心、呕吐、延迟性腹泻、急性胆碱能综合征等，程度较轻，无化疗相关死亡。结论恩度联合FOLFIRI治疗晚期大肠癌具有协同作用，疗效肯定，毒副反应能够耐受。
목적：탐토중조인혈관내피억제소주사액（은도）연합FOLFIRI방안치료만기대장암적료효화불량반응。방법대40례초치혹복치만기대장암환자채용은도연합FOLFIRI방안치료，2주기후평개료효。결과40례환자공완성80주기치료，가평개료효급불량반응，총유효솔위39.1％，불량반응주요표현위골수억제백세포감소、악심、구토、연지성복사、급성담감능종합정등，정도교경，무화료상관사망。결론은도연합FOLFIRI치료만기대장암구유협동작용，료효긍정，독부반응능구내수。
Objective To investigate the curative effect and adverse reaction of the recombi-nant human endostatin injection ( endostar ) combined with FOLFIRI regimen in the treatment of advanced colorectal cancer .Methods Forty patients with advanced colorectal cancer in ini-tial treatment or retreatment by using endostar combined with FOLFIRI regimen were evaluated after 2 cycles.Results Forty patients completed 80 cycles of treatment , and curative effect and adverse reaction could be evaluated .The total effective rate was 39.1%, and the main side effects were neutropenia , nausea , vomiting , delayed diarrhea , acute cholinergic syn-drome, to a lesser extent , and no chemotherapy related death .Conclusion Endostar com-bined with FOLFIRI have a synergistic effect in treatment of advanced colorectal cancer with therapeutic efficacy , and toxicity can be tolerated .