CAJ | 학술논문

目的：探讨致癌基因促分裂原活化蛋白激酶活化蛋白激酶2（MAPKAPK2）的表达水平在非小细胞肺癌（NSCLC）预后中的评估价值．方法：采用免疫组化方法检测200例NSCLC组织中MAPKAPK2基因的蛋白表达量，采用Log-rank检验和COX回归分析MAPKAPK2表达与NSCLC预后的关联，并用时间依赖的ROC曲线探讨其预测价值．结果：NSCLC患者中位生存期随MAPKAPK2表达分级而显著缩短（低∶中∶高：22个月∶15个月∶8个月；Log-rank检验P＝2.51×10-6）；MAPKAPK2高表达组患者较低表达患者死亡率增加（HR＝3.02，95％CI＝1.86-4.92）．NSCLC五年生存率下，MAPKAPK2表达的ROC曲线下面积值可达0.711．结论：MAPKAPK2高表达可增加肺癌患者的死亡风险，对NSCLC患者的预后具有较好的预测价值．
목적：탐토치암기인촉분렬원활화단백격매활화단백격매2（MAPKAPK2）적표체수평재비소세포폐암（NSCLC）예후중적평고개치．방법：채용면역조화방법검측200례NSCLC조직중MAPKAPK2기인적단백표체량，채용Log-rank검험화COX회귀분석MAPKAPK2표체여NSCLC예후적관련，병용시간의뢰적ROC곡선탐토기예측개치．결과：NSCLC환자중위생존기수MAPKAPK2표체분급이현저축단（저∶중∶고：22개월∶15개월∶8개월；Log-rank검험P＝2.51×10-6）；MAPKAPK2고표체조환자교저표체환자사망솔증가（HR＝3.02，95％CI＝1.86-4.92）．NSCLC오년생존솔하，MAPKAPK2표체적ROC곡선하면적치가체0.711．결론：MAPKAPK2고표체가증가폐암환자적사망풍험，대NSCLC환자적예후구유교호적예측개치．
Aim:To investigate the predictive value of MAPKAPK2 expression on survival of non-small cell lung cancer (NSCLC).Methods:The protein expression of MAPKAPK2 was examined using the immunohistochemical staining in 200 cases of NSCLC tissues.The effect of MAPKAPK2 expression on lung cancer survival was tested by the Log-rank test and COX model,and its predictive value was esti-mated by the time-dependent ROC curve.Results:The median survival time of NSCLC patients was de-creased significantly along with the increased expression of MAPKAPK2 (Low vs.Moderate vs.High:22 months vs.1 5 months vs.8 months;Log-rank test:P=2.51 ×1 0 -6 ).Compared to individuals with low MAPKAPK2 expression in cancer tissues,those with high MAPKAPK2 expression exerted a significantly higher lung cancer mortality (HR=3.02,95%CI=1.86 -4.92).The area under the ROC curve of MAPKAPK2 was 0.71 1 .Conclusion:High expression of MAPKAPK2 significantly worsen the prognosis of NSCLC,which might be a value predictive biomarker of NSCLC.