CAJ | 학술논문

目的：探讨脑静脉系统血栓形成（CVT）合并颅内出血后应用抗凝药物的疗效及风险。方法：连续收集CVT合并颅内出血的住院患者16例，确诊后给予低分子肝素抗凝治疗，通过每周1次头颅CT观察血肿体积动态变化，动态MRV观察血栓再通情况，并记录出血并发症的发生。结果：抗凝治疗前基线血肿体积为（13.9±3.7）mL，应用低分子肝素抗凝治疗1周后复查头颅CT测血肿体积为（10.1±2.7）mL，均无血肿扩大，8例明显吸收，2周复查头颅CT血肿体积（5.2±3.3）mL，血肿均吸收≥75%。无严重出血性并发症，14 d MRV复查15例血管再通。结论：抗凝治疗是CVT合并颅内出血的安全有效方法，尽早抗凝治疗可有效缓解症状，改善患者预后。
목적：탐토뇌정맥계통혈전형성（CVT）합병로내출혈후응용항응약물적료효급풍험。방법：련속수집CVT합병로내출혈적주원환자16례，학진후급여저분자간소항응치료，통과매주1차두로CT관찰혈종체적동태변화，동태MRV관찰혈전재통정황，병기록출혈병발증적발생。결과：항응치료전기선혈종체적위（13.9±3.7）mL，응용저분자간소항응치료1주후복사두로CT측혈종체적위（10.1±2.7）mL，균무혈종확대，8례명현흡수，2주복사두로CT혈종체적（5.2±3.3）mL，혈종균흡수≥75%。무엄중출혈성병발증，14 d MRV복사15례혈관재통。결론：항응치료시CVT합병로내출혈적안전유효방법，진조항응치료가유효완해증상，개선환자예후。
ObjectiveTo investigate the effect and risk of anticoagulant therapy for patients with cerebral venous thrombosis accompanied by intracranial hemorrhage. Methods:Sixteen patients with cerebral venous thrombosis accompanied by intracranial hemorrhage were collected from the in-patient department. The clinical information was recorded in detail. Low molecular heparin was given after the definite diagnosis was made. CT scan was used to observe the dynamic change of hematoma volume. MRV was used to determine the recanalization. Any bleeding complications were documented. Results:The baseline hematoma volume was (13.9±3.7)mL. One week after anticoagulant therapy, the hematoma volume was shrinked to to (10.1±2.7)mL. CT scan did not show expansion of hematoma volume and the hematoma volume was obviously reduced in 8 patients (50%). The hematoma volume was reduced to (5.2±3.3)mL two weeks after anticoagulant therapy. No serious bleeding com-plications were observed. Recanalization was observed by MRV in 15 patients two weeks after anticoagulant therapy. Conclusion: Anticoagulant therapy is a safe and effective therapy for patients with cerebral venous thrombosis accompanied by intracranial hemorrhage. Early anticoagulant therapy can improve the symptoms and prognosis of these patients.