神经损伤与功能重建
神經損傷與功能重建
신경손상여공능중건
NEURAL INJURY AND FUNCTIONAL RECONSTRUCTION
2014年
1期
20-23
,共4页
急性脑梗死%血小板平均体积%纤维蛋白原%神经功能缺损
急性腦梗死%血小闆平均體積%纖維蛋白原%神經功能缺損
급성뇌경사%혈소판평균체적%섬유단백원%신경공능결손
acute cerebral infarction%mean platelet volume%fibrinogen%neurological deficit
目的：探讨纤维蛋白原（FIB）和血小板平均体积（MPV）与急性脑梗死（ACI）的关系。方法：分析429例ACI患者（ACI组）和429例非脑梗死患者（对照组）的血小板和凝血系统相关参数水平，并根据ACI组的美国国立卫生研究院卒中量表（NIHSS）评分将ACI组分为轻、中、重度亚组。结果：与对照组比较，ACI组的PLT水平显著降低（＜0.01），MPV、血小板分布宽度（PDW）及纤维蛋白原（FIB）水平显著升高（＜0.01）。多因素 Logistic 回归分析显示，MPV和FIB与脑梗死呈独立相关（＝1.628，为1.427~1.857；＝7.115，为4.981~10.164）；FIB与MPV水平两者相互间无明显相关性。ACI组各亚组FIB水平两两比较差异有统计学意义（＜0.01），ACI患者FIB水平与NIHSS评分呈正相关（＝0.451，＜0.01）。结论：FIB、MPV可能为引起急性脑梗死的重要危险因素，且FIB与病情的严重程度呈显著正相关。
目的：探討纖維蛋白原（FIB）和血小闆平均體積（MPV）與急性腦梗死（ACI）的關繫。方法：分析429例ACI患者（ACI組）和429例非腦梗死患者（對照組）的血小闆和凝血繫統相關參數水平，併根據ACI組的美國國立衛生研究院卒中量錶（NIHSS）評分將ACI組分為輕、中、重度亞組。結果：與對照組比較，ACI組的PLT水平顯著降低（＜0.01），MPV、血小闆分佈寬度（PDW）及纖維蛋白原（FIB）水平顯著升高（＜0.01）。多因素 Logistic 迴歸分析顯示，MPV和FIB與腦梗死呈獨立相關（＝1.628，為1.427~1.857；＝7.115，為4.981~10.164）；FIB與MPV水平兩者相互間無明顯相關性。ACI組各亞組FIB水平兩兩比較差異有統計學意義（＜0.01），ACI患者FIB水平與NIHSS評分呈正相關（＝0.451，＜0.01）。結論：FIB、MPV可能為引起急性腦梗死的重要危險因素，且FIB與病情的嚴重程度呈顯著正相關。
목적：탐토섬유단백원（FIB）화혈소판평균체적（MPV）여급성뇌경사（ACI）적관계。방법：분석429례ACI환자（ACI조）화429례비뇌경사환자（대조조）적혈소판화응혈계통상관삼수수평，병근거ACI조적미국국립위생연구원졸중량표（NIHSS）평분장ACI조분위경、중、중도아조。결과：여대조조비교，ACI조적PLT수평현저강저（＜0.01），MPV、혈소판분포관도（PDW）급섬유단백원（FIB）수평현저승고（＜0.01）。다인소 Logistic 회귀분석현시，MPV화FIB여뇌경사정독립상관（＝1.628，위1.427~1.857；＝7.115，위4.981~10.164）；FIB여MPV수평량자상호간무명현상관성。ACI조각아조FIB수평량량비교차이유통계학의의（＜0.01），ACI환자FIB수평여NIHSS평분정정상관（＝0.451，＜0.01）。결론：FIB、MPV가능위인기급성뇌경사적중요위험인소，차FIB여병정적엄중정도정현저정상관。
ObjectiveTo investigate the relationship of fibrinogen (FIB), mean platelet volume (MPV) and acute cerebral infarction (ACI). Methods:The level of platelets system platelets (PLT), MPV, plateletcrit, platelet distri-bution width (PDW) and the coagulation system (prothrombin time, international normalized ratio, FIB, activated partial thromboplastin time) of 429 ACI cases (ACI group) and 429 cases of Non-cerebral infarction group (con-trol group) were analyzed. According to the National Institutes of Health stroke Scale (NIHSS) in ACI pa-tients, the ACI group was divided into mild, moderate and severe subgroups. Results:Compared with the con-trol group, the PLT levels were significantly lower ( <0.01) whereas the MPV, PDW and FIB levels were signif-icantly higher ( <0.01) in ACI group. Logistic regression analysis showed that MPV and FIB were independently associated with ACI ( =1.628, 95% :1.427~1 .857;=7.115,95% :4.981~10.164). The FIB level showed no significant correlation with MPV level. The FIB levels between the subgroups of ACI group were sig-nificantly different ( <0.01). In ACI patients, the FIB levels and NIHSS score were positively correlated (=0.451, <0.01). Conclusion:FIB and MPV levels may be the important risk factors for ACI.
