CAJ | 학술논문

目的：研究不同年龄组Tg-SwDI小鼠与同龄野生型（WT）小鼠筑巢行为的差异。方法：将小鼠按基因（Tg-SwDI和WT）和年龄（2~4月龄、10~12月龄、18~20月龄）分为6组，利用固有筑巢材料在群养小鼠家笼中进行集体筑巢行为实验，之后利用纸巾进行个体筑巢实验。结果：基因（F1,31=37.03，＜0.0001）和年龄因素（F2,31=3.88，＜0.05）对群体筑巢评分均有影响。Tg-SwDI小鼠与WT小鼠相比，各年龄组均有群体筑巢功能的下降。在个体筑巢实验中，2~4月龄和10~12月龄Tg-SwDI小鼠的个体筑巢功能下降不明显，18~20月龄组有显著变化。方差分析提示显著的基因（F1,135=23.64，＜0.0001）和年龄（F2,135=15.46，＜0.0001）影响。结论：Tg-SwDI小鼠可较早出现集体筑巢行为受损，可能反映其早期社交行为改变，与执行功能相关的个体筑巢行为较晚才出现明显下降。
목적：연구불동년령조Tg-SwDI소서여동령야생형（WT）소서축소행위적차이。방법：장소서안기인（Tg-SwDI화WT）화년령（2~4월령、10~12월령、18~20월령）분위6조，이용고유축소재료재군양소서가롱중진행집체축소행위실험，지후이용지건진행개체축소실험。결과：기인（F1,31=37.03，＜0.0001）화년령인소（F2,31=3.88，＜0.05）대군체축소평분균유영향。Tg-SwDI소서여WT소서상비，각년령조균유군체축소공능적하강。재개체축소실험중，2~4월령화10~12월령Tg-SwDI소서적개체축소공능하강불명현，18~20월령조유현저변화。방차분석제시현저적기인（F1,135=23.64，＜0.0001）화년령（F2,135=15.46，＜0.0001）영향。결론：Tg-SwDI소서가교조출현집체축소행위수손，가능반영기조기사교행위개변，여집행공능상관적개체축소행위교만재출현명현하강。
ObjectiveTo investigate the differences in the nesting behaviour between Tg-SwDI transgenic mice and wild-type (WT) mice. Methods: Transgenic Tg-SwDI (Tg) and wild-type (WT) mice have been studied to observe their group nest-building behaviors with chip shavings and individual nest-building behaviors with paper towels. Results: The genotype(F1,31=37.03, <0.0001)and age(F2,31=3.88, <0.05)had effect on the group nest construction, and the same on the individual nest-building. However, there were no significant differences between Tg and WT mice until 18~20 months. Conclusion:The Tg-SwDI transgenic mice showed a worse nest-ing compared to WT mice at the early ages when they were group-housed. Most individually housed mice in each group showed impaired nesting behavior in old age (18~20 months).