CAJ | 학술논문

目的：研究拉米夫定（LAM）联合恩替卡韦（ETV）治疗乙型肝炎后肝硬化的临床效果及对患者生存质量的影响。方法选取乙型肝炎后肝硬化患者68例，均给予LAM（100 mg/d）联合ETV（0．5 mg/d）抗病毒治疗，疗程为4个月，观察记录治疗前后相关肝功能指标、Child-Pugh评分及健康生存质量量表（SF-36）评分，以判断抗病毒治疗对乙型肝炎后肝硬化的疗效。结果经4个月治疗后，患者肝功能指标、Child-Pugh评分均较治疗前降低（ P ＜0．01）；SF-36评分升高（ P ＜0．01）。结论对乙型肝炎后肝硬化患者行抗病毒治疗，可有效改善患者肝功能，降低Child-Pugh评分，提高生存质量。
목적：연구랍미부정（LAM）연합은체잡위（ETV）치료을형간염후간경화적림상효과급대환자생존질량적영향。방법선취을형간염후간경화환자68례，균급여LAM（100 mg/d）연합ETV（0．5 mg/d）항병독치료，료정위4개월，관찰기록치료전후상관간공능지표、Child-Pugh평분급건강생존질량량표（SF-36）평분，이판단항병독치료대을형간염후간경화적료효。결과경4개월치료후，환자간공능지표、Child-Pugh평분균교치료전강저（ P ＜0．01）；SF-36평분승고（ P ＜0．01）。결론대을형간염후간경화환자행항병독치료，가유효개선환자간공능，강저Child-Pugh평분，제고생존질량。
Objective To study the efficacy and quality of life assessment of lamivudine (LAM) combined with entecavir ( ETV) in the treatment of patients with liver cirrhosis after hepatitis B .Methods Sixty-eight patients with viral cirrhosis were given a dose of LAM(100 mg/d)and ETV(0.5 mg/d),the course was 4 months.Before and after the treatment ,the patients were tested for the liver function,Child-Pugh score and health and quality of life (SF-36) score.By comparing the differences before and after treatment , the efficacy of antiviral treatment of liver cirrhosis after hepatitis B and quality of life were evaluated .Results After a course of four months,the liver function and Child-Pugh score of all the patients were improved ( P <0.01),and SF-36 score was higher than before ( P <0.01).Conclusion Antiviral therapy can effectively improve hepatic function ,lower Child-Pugh score and improve the quality of life of patients with liver cirrhosis after hepatitis B .