CAJ | 학술논문

目的：探讨低分子肝素与奥扎格雷钠联用治疗急性脑梗死患者的临床疗效。方法将116例急性脑梗死患者随机分为两组，各58例。对照组进行常规治疗，观察组同时给予低分子肝素联合奥扎格雷钠治疗，比较治疗后两组的临床疗效、神经功能缺损评分（ NIHSS）、日常生活能力评分（ ADL）及不良反应情况。结果观察组治疗总有效率为94．8％，明显高于对照组的70．7％（ P ＜0．01）；两组治疗后NIHSS均降低，ADL 均增加；观察组NIHSS明显低于对照组，ADL明显高于对照组（ P ＜0．01）；两组不良反应发生率差异无统计学意义（ P ＞0．05）。结论低分子肝素与奥扎格雷钠联用治疗急性脑梗死效果较好，可明显提高临床疗效，改善神经功能及日常生活能力。
목적：탐토저분자간소여오찰격뢰납련용치료급성뇌경사환자적림상료효。방법장116례급성뇌경사환자수궤분위량조，각58례。대조조진행상규치료，관찰조동시급여저분자간소연합오찰격뢰납치료，비교치료후량조적림상료효、신경공능결손평분（ NIHSS）、일상생활능력평분（ ADL）급불량반응정황。결과관찰조치료총유효솔위94．8％，명현고우대조조적70．7％（ P ＜0．01）；량조치료후NIHSS균강저，ADL 균증가；관찰조NIHSS명현저우대조조，ADL명현고우대조조（ P ＜0．01）；량조불량반응발생솔차이무통계학의의（ P ＞0．05）。결론저분자간소여오찰격뢰납련용치료급성뇌경사효과교호，가명현제고림상료효，개선신경공능급일상생활능력。
Objective To study the clinical curative effect of low molecular heparin with the sodium ozagrel combined treat -ment in patients with acute cerebral infarction .Methods One hundred and sixteen cases of acute cerebral infarction were randomly di -vided into two groups .The control group underwent conventional treatment ,and the experimental group was given low molecular heparin combined with sodium ozagrel treatment .The clinical curative effect ,NIHSS and ability of daily life ( ADL) and adverse reactions of the two groups were compared.Results The treatment efficiency of the experimental group (94.8%)was obviously higher than that of control group ( P <0.01).Nerve function defect scores decreased and daily life ability scores increased in both groups after thetreat -ment .NIHSS of the experimental group was significantly lower than that of the control group ,and daily life ability score was significantly higher than that of the control group ( P <0.01).There was no significant difference between the incidence rates of adverse reaction of the two groups( P >0.05).Conclusion Low molecular heparin combined with sodium ozagrel in treatment of acute cerebral infarc -tion can obviously increase the clinical curative effect ,and improve nerve function and ADL of the patients .