CAJ | 학술논문

目的：探讨阿昔洛韦联合纳洛酮治疗病毒性脑炎的临床疗效。方法将符合标准的124例病毒性脑炎患儿随机分成观察组和对照组各62例，对照组在常规治疗基础上单用阿昔洛韦静滴，观察组在对照组基础加用纳洛酮静滴。观察2组患儿的症状和体征改善情况、血清炎症因子指标、临床疗效以及后遗症情况。结果观察组的脑电图、脑脊液恢复时间及其头痛、惊厥、抽搐、意识障碍、脑膜刺激征消失时间均显著短于对照组（P＜0.05）；治疗后观察组血清 NSE、S-100β以及MMP-9水平较治疗前及对照组明显降低（P＜0.05）；观察组临床总有效率明显高于对照组，后遗症发生率明显低于对照组（P＜0.05）。结论阿昔洛韦联合纳洛酮治疗小儿病毒性脑炎的临床效果十分显著，有效降低后遗症发生率，值得临床推广应用。
목적：탐토아석락위연합납락동치료병독성뇌염적림상료효。방법장부합표준적124례병독성뇌염환인수궤분성관찰조화대조조각62례，대조조재상규치료기출상단용아석락위정적，관찰조재대조조기출가용납락동정적。관찰2조환인적증상화체정개선정황、혈청염증인자지표、림상료효이급후유증정황。결과관찰조적뇌전도、뇌척액회복시간급기두통、량궐、추휵、의식장애、뇌막자격정소실시간균현저단우대조조（P＜0.05）；치료후관찰조혈청 NSE、S-100β이급MMP-9수평교치료전급대조조명현강저（P＜0.05）；관찰조림상총유효솔명현고우대조조，후유증발생솔명현저우대조조（P＜0.05）。결론아석락위연합납락동치료소인병독성뇌염적림상효과십분현저，유효강저후유증발생솔，치득림상추엄응용。
Objective To explore the role of acyclovir combined with naloxone on children with viral encephalitis.Methods One hundred ard twenty-four patients with this disease were randomly divided into observation group (62 cases) and control group (62 cases) ,patients in control group were treated with acyclovir ,while others were treared with acyclovir and nalox-one.The improvement of clinical symptoms and signs ,biochemical indicators ,total treatment efficiency and treatment sequelae were observed in all patients.Results The recovery time of EEG and cerebrospinal fluid and the disappearance time of head-aches ,convulsions ,seizures ,unconsciousness ,meningeal irritation of observation group were significantly shorter than those of the control group (P<0.05).The level of NSE ,S-100βand MMP-9 in observation group were significantly lower than those of control group (P<0.05).The total effective rate of the observation group was significantly higher than that of the control group (P<0.05) ,and the treatment sequelae rate of the observation group was significantly lower than that of the control group (P<0.05).Conclusion The clinical effect of Acyclovir combined with naloxone on children with viral encephalitis is sig-nificant ,sequelae incidence is effectively reduced ,it is worth of promotion in clinical treatment.