CAJ | 학술논문

目的：比较地佐辛与哌替啶治疗急性结石性胆绞疼的疗效及不良反应，为急诊临床用药提供参考。方法采用地佐辛+阿托品肌肉注射治疗急性结石性胆绞痛（研究组），以哌替啶+阿托品治为对照组，观察其疗效及药物不良反应。结果研究组与对照组比较，总有效率差异无统计学意义（P>0.05），研究组疼痛复发率降低，与对照组相比，差异具有统计学意义（P<0.05）。恶心呕吐、眩晕、皮肤瘙痒等药物不良反应研究组明显低于对照组，差异具有统计学意义（P<0.05）。结论地佐辛肌肉注射对急性结石性胆绞痛有明显的镇痛作用，可作为治疗急性结石性胆绞痛的急诊用药。
목적：비교지좌신여고체정치료급성결석성담교동적료효급불량반응，위급진림상용약제공삼고。방법채용지좌신+아탁품기육주사치료급성결석성담교통（연구조），이고체정+아탁품치위대조조，관찰기료효급약물불량반응。결과연구조여대조조비교，총유효솔차이무통계학의의（P>0.05），연구조동통복발솔강저，여대조조상비，차이구유통계학의의（P<0.05）。악심구토、현훈、피부소양등약물불량반응연구조명현저우대조조，차이구유통계학의의（P<0.05）。결론지좌신기육주사대급성결석성담교통유명현적진통작용，가작위치료급성결석성담교통적급진용약。
Objective:To compare the curative effects and ADRs of dezocine and pethidine on acute cholecyst colic of calculi. Methods: The acute cholecyst colic of calculi was therapy by intramuscular injection of dezocine and atropine (test group), meanwhile pethidine and atropine was used control ed group to observe the curative effects and ADRs. Results:Compared with the control group, the difference of total effective rate of the test group was no statistical significant (P >0.05), and the relapse rate was significantly lower, the difference had statistical significant (P <0.05). The adverse drug reactions such as nausea, vomiting, dizziness, skin itching etc. test group was significantly lower than the control group, the difference was statistical y significant (P <0.05). Conclusion: Intramuscular injection of dezocine has good analgesic effect in acute cholecyst colic of calculi and it could be used as the treatment of acute cholecyst colic of calculi in emergency department of hospital.