CAJ | 학술논문

目的：探讨拉米夫定治疗儿童慢性乙型肝炎的临床疗效及安全性。方法将我院2011年12月至2012年11月收治的儿童慢性乙型肝炎患者40例纳入本研究，随机分组。对照组接受常规治疗，实验组接受拉米夫定治疗。连续用药12个月，对比两组患童在临床疗效和安全性方面的差异性。结果与对照组对比，我们发现实验组患童总有效率明显较高，组间差异经统计学分析后认为有意义（p＜0.05）。对比两组不良反应发现，组间差异统计学分析后认为无意义（p＞0.05）。结论拉米夫定用于治疗儿童慢性乙型肝炎具有疗效显著、不良反应轻微等优越性，今后可将其作为儿童慢性乙型肝炎治疗的有效方案进行推广应用。
목적：탐토랍미부정치료인동만성을형간염적림상료효급안전성。방법장아원2011년12월지2012년11월수치적인동만성을형간염환자40례납입본연구，수궤분조。대조조접수상규치료，실험조접수랍미부정치료。련속용약12개월，대비량조환동재림상료효화안전성방면적차이성。결과여대조조대비，아문발현실험조환동총유효솔명현교고，조간차이경통계학분석후인위유의의（p＜0.05）。대비량조불량반응발현，조간차이통계학분석후인위무의의（p＞0.05）。결론랍미부정용우치료인동만성을형간염구유료효현저、불량반응경미등우월성，금후가장기작위인동만성을형간염치료적유효방안진행추엄응용。
Objective Investigate the clinical efficacy and safety of lamivudine in the treatment of chronic hepatitis B in children. Methods Choose 40 cases with chronic hepatitis B in children in our hospital from Dec. 2011 to Nov. 2012 in our hospital included in the study, randomized grouping. Control group received routine treatment, Experimental group received lamivudine therapy. After 12 months, the differences in clinical efficacy and safety of comparing the two groups of children. Results Compared with control group, we found that experimental group children total efficiency is significantly higher, the differences between groups were analyzed statistical y significant (P < 0.05). Compared of adverse reaction in the two groups after statistical analysis, the differences between groups that no significance (P > 0.05). Conclusion Lamivudine for the treatment of chronic hepatitis B in children has significant efficacy, mild adverse reactions superiority, can be applied as effective for children in chronic hepatitis B treatment.