CAJ | 학술논문

目的：探讨了肺炎支原体肺炎患儿治疗前后血清IL-2,IL-8和β-防御素-2水平的变化及临床意义。方法应用放射免疫法和酶联法对33例肺炎支原体肺炎患儿进行了治疗前后血清I L-2, I L-8和β-防御素-2水平检测，并与35名正常健康儿作比较。结果肺炎支原体肺炎患儿在治疗前血清I L-2,β-防御素-2水平非常显著地低于正常儿组（P<0.01）,而IL-8水平又非常显著地高于正常儿组（P<0.01）,经治疗2周后则与正常人比较无显著性差异（P>0.05）,血清IL-8水平与IL-2，β-防御素-2水平呈显著免相差（r=-0.4782,-0.5018,P<0.01）.结论血清IL-2，IL-8和β-防御素-2参与了肺炎支原体感染的全过程，检测这些细胞因子的变化有助于诊断，治疗和预后，具有一定的临床价值。
목적：탐토료폐염지원체폐염환인치료전후혈청IL-2,IL-8화β-방어소-2수평적변화급림상의의。방법응용방사면역법화매련법대33례폐염지원체폐염환인진행료치료전후혈청I L-2, I L-8화β-방어소-2수평검측，병여35명정상건강인작비교。결과폐염지원체폐염환인재치료전혈청I L-2,β-방어소-2수평비상현저지저우정상인조（P<0.01）,이IL-8수평우비상현저지고우정상인조（P<0.01）,경치료2주후칙여정상인비교무현저성차이（P>0.05）,혈청IL-8수평여IL-2，β-방어소-2수평정현저면상차（r=-0.4782,-0.5018,P<0.01）.결론혈청IL-2，IL-8화β-방어소-2삼여료폐염지원체감염적전과정，검측저사세포인자적변화유조우진단，치료화예후，구유일정적림상개치。
Objective:To explore the Clinical Significance of changes of Serum IL-2,IL-8 and Beta-Defensin-2 levels after treatment in pediatric patients with mycoplasma pneumonia.Methods:Serum IL-2,IL-8(with RIA),Serum Beta-Defensin-2 (with ELISA) levels were determined in 33 patients and 35 normal healthy children.Results:Before treatment,Serum IL-2,Beta-Defensin-2 levels were Significantly lower than those in Controls(P<0.01),but serum IL-8 levels were significantly higher than those in controls (P<0.01).after treatment for 2 weeks the levels in patients manifested no more different from those in controls(P>0.05),Serum IL-8 levels was negative correlated with serum IL-2 levels ,beta-Defensin-2 levels(r=-0.4782,-0.5018,P<0.01).Conclusions:The cytokines IL-2,IL-8 and keta-Defensin-2 might participate in the whole process of my coplasma infection,monitoring the changes of these cytokines could be healptul to the diagnosis, treatment and prognosis of the diseases and provides certain clinical values.