CAJ | 학술논문

丙烯酰胺(acrylamide, AA)是含淀粉类食品经过120℃以上高温加热后产生的,有研究表明AA对机体有生殖毒性、发育毒性、神经毒性和基因毒性等,尤其是AA的生殖毒性和发育毒性逐渐引起了人们的广泛关注。在AA的生殖毒性和发育毒性研究中,任何反映生殖系统损伤的指标均可作为AA生殖毒性的生物标志物；同样,所有能反应发育毒性终点的指标均可作为AA发育毒性的生物标志物。随着越来越多的生物标志物的确定,其在安全性评价中也将发挥重要的作用。因此,生物标志物的研究对综合评价AA的生殖毒性和发育毒性有非常重要的意义。本文综述了国内外对AA的生殖毒性和发育毒性生物标志物的研究进展,为AA这两种毒性评价指标的选择提供参考。
병희선알(acrylamide, AA)시함정분류식품경과120℃이상고온가열후산생적,유연구표명AA대궤체유생식독성、발육독성、신경독성화기인독성등,우기시AA적생식독성화발육독성축점인기료인문적엄범관주。재AA적생식독성화발육독성연구중,임하반영생식계통손상적지표균가작위AA생식독성적생물표지물；동양,소유능반응발육독성종점적지표균가작위AA발육독성적생물표지물。수착월래월다적생물표지물적학정,기재안전성평개중야장발휘중요적작용。인차,생물표지물적연구대종합평개AA적생식독성화발육독성유비상중요적의의。본문종술료국내외대AA적생식독성화발육독성생물표지물적연구진전,위AA저량충독성평개지표적선택제공삼고。
Acrylamide (AA) is primarily generated in starchy food which heated up to 120 ℃. Researches showed that AA had reproductive toxicity, developmental toxicity, neurotoxicity and genetic toxicity to the body. Especially, the reproductive and developmental toxicity of AA attracted a great of attentions gradually. In the research of reproductive toxicity and developmental toxicity of AA, any indexes reflected reproductive system damage could be used as biomarkers of AA reproductive toxicity. As the same, any indexes reflected developmental system damage could also be used as biomarkers of AA developmental toxicity. As more and more biomarkers have been determined, they will play an important role in the risk assessment. Therefore, the evaluation of biomarker has very important significance in comprehensive research of AA reproductive and developmental toxicity. This paper reviewed the biomarker of reproductive and developmental toxicity of AA, and described them from various perspectives.