畜牧与饲料科学
畜牧與飼料科學
축목여사료과학
ANIMAL HUSBANDRY AND FEED SCIENCE
2014年
2期
1-3
,共3页
郑润宽%李霞%付改玲%高永刚%马亚囡
鄭潤寬%李霞%付改玲%高永剛%馬亞囡
정윤관%리하%부개령%고영강%마아닙
羊胎盘转移因子注射液%血浆总蛋白%白蛋白%超氧化物歧化酶%一氧化氮%血红蛋白%营养
羊胎盤轉移因子註射液%血漿總蛋白%白蛋白%超氧化物歧化酶%一氧化氮%血紅蛋白%營養
양태반전이인자주사액%혈장총단백%백단백%초양화물기화매%일양화담%혈홍단백%영양
sheep placental transfer factor%plasma total protein%albumin%superoxide dismutase%nitric oxide%hemoglobin%nutrition
[目的]通过研究羊胎盘转移因子注射液对健康大白鼠、人工创伤模型大白鼠和健康杂种幼犬的血浆总蛋白（TP）、白蛋白（ALB）、超氧化物歧化酶（SOD）、一氧化氮（NO）和血红蛋白（Hb）含量的影响，探讨供试药品对受试动物的营养作用，进而评估其临床营养功效。[方法]将24只健康大鼠和16只健康杂种幼犬分别随机分为试验组和对照组，为试验组大鼠和试验组幼犬灌服供试药品，并检测给药前后血浆TP、ALB和Hb含量的变化。将45只健康大鼠人工创伤造模后分成低剂量试验组、中剂量试验组和对照组3个组，试验组大鼠使用不同剂量供试药品，于术后3、7、14 d测定血浆TP、ALB、SOD和NO含量的变化。[结果]①为健康大鼠灌服供试药品后，与对照组相比，试验组健康大鼠血浆TP、ALB含量显著（P<0.05）提高。②为健康杂种幼犬灌服供试药品后3 d，与对照组相比，试验组健康杂种幼犬血浆中TP、Hb含量均极显著（P<0.01）提高，ALB含量显著（P<0.05）提高。③为人工创伤模型大鼠灌服供试药品后，与对照组相比，各试验组术后3 d血浆TP、ALB、NO含量均提高；术后7 d中剂量组血浆TP、ALB、NO含量均极显著提高（P<0.01），低剂量组显著提高（P＜0.05）；术后14 d，试验组血浆TP、ALB含量恢复到术前，试验组血浆NO含量升高，无显著差异（P＞0.05）。与对照组相比，术后3 d和7 d，各试验组血浆SOD含量升高，无显著差异（P＞0.05）；术后14 d，各试验组SOD含量升高，中剂量组显著（P＜0.05）升高。[结论]羊胎盘转移因子注射液可显著改善健康大鼠和健康杂种幼犬的营养状况，促进术后大鼠创伤恢复和幼犬的生长发育，提高机体抗病能力，在临床上兼具改善营养和提高免疫力的作用。
[目的]通過研究羊胎盤轉移因子註射液對健康大白鼠、人工創傷模型大白鼠和健康雜種幼犬的血漿總蛋白（TP）、白蛋白（ALB）、超氧化物歧化酶（SOD）、一氧化氮（NO）和血紅蛋白（Hb）含量的影響，探討供試藥品對受試動物的營養作用，進而評估其臨床營養功效。[方法]將24隻健康大鼠和16隻健康雜種幼犬分彆隨機分為試驗組和對照組，為試驗組大鼠和試驗組幼犬灌服供試藥品，併檢測給藥前後血漿TP、ALB和Hb含量的變化。將45隻健康大鼠人工創傷造模後分成低劑量試驗組、中劑量試驗組和對照組3箇組，試驗組大鼠使用不同劑量供試藥品，于術後3、7、14 d測定血漿TP、ALB、SOD和NO含量的變化。[結果]①為健康大鼠灌服供試藥品後，與對照組相比，試驗組健康大鼠血漿TP、ALB含量顯著（P<0.05）提高。②為健康雜種幼犬灌服供試藥品後3 d，與對照組相比，試驗組健康雜種幼犬血漿中TP、Hb含量均極顯著（P<0.01）提高，ALB含量顯著（P<0.05）提高。③為人工創傷模型大鼠灌服供試藥品後，與對照組相比，各試驗組術後3 d血漿TP、ALB、NO含量均提高；術後7 d中劑量組血漿TP、ALB、NO含量均極顯著提高（P<0.01），低劑量組顯著提高（P＜0.05）；術後14 d，試驗組血漿TP、ALB含量恢複到術前，試驗組血漿NO含量升高，無顯著差異（P＞0.05）。與對照組相比，術後3 d和7 d，各試驗組血漿SOD含量升高，無顯著差異（P＞0.05）；術後14 d，各試驗組SOD含量升高，中劑量組顯著（P＜0.05）升高。[結論]羊胎盤轉移因子註射液可顯著改善健康大鼠和健康雜種幼犬的營養狀況，促進術後大鼠創傷恢複和幼犬的生長髮育，提高機體抗病能力，在臨床上兼具改善營養和提高免疫力的作用。
[목적]통과연구양태반전이인자주사액대건강대백서、인공창상모형대백서화건강잡충유견적혈장총단백（TP）、백단백（ALB）、초양화물기화매（SOD）、일양화담（NO）화혈홍단백（Hb）함량적영향，탐토공시약품대수시동물적영양작용，진이평고기림상영양공효。[방법]장24지건강대서화16지건강잡충유견분별수궤분위시험조화대조조，위시험조대서화시험조유견관복공시약품，병검측급약전후혈장TP、ALB화Hb함량적변화。장45지건강대서인공창상조모후분성저제량시험조、중제량시험조화대조조3개조，시험조대서사용불동제량공시약품，우술후3、7、14 d측정혈장TP、ALB、SOD화NO함량적변화。[결과]①위건강대서관복공시약품후，여대조조상비，시험조건강대서혈장TP、ALB함량현저（P<0.05）제고。②위건강잡충유견관복공시약품후3 d，여대조조상비，시험조건강잡충유견혈장중TP、Hb함량균겁현저（P<0.01）제고，ALB함량현저（P<0.05）제고。③위인공창상모형대서관복공시약품후，여대조조상비，각시험조술후3 d혈장TP、ALB、NO함량균제고；술후7 d중제량조혈장TP、ALB、NO함량균겁현저제고（P<0.01），저제량조현저제고（P＜0.05）；술후14 d，시험조혈장TP、ALB함량회복도술전，시험조혈장NO함량승고，무현저차이（P＞0.05）。여대조조상비，술후3 d화7 d，각시험조혈장SOD함량승고，무현저차이（P＞0.05）；술후14 d，각시험조SOD함량승고，중제량조현저（P＜0.05）승고。[결론]양태반전이인자주사액가현저개선건강대서화건강잡충유견적영양상황，촉진술후대서창상회복화유견적생장발육，제고궤체항병능력，재림상상겸구개선영양화제고면역력적작용。
[Objective] The research aimed to study effects of sheep placental transfer factor (SPTF) on the contents of total protein(TP), albumin(ALB), superoxide dismutase (SOD),nitric oxide(NO) and hemoglobin(Hb) in the plasm of healthy rats, artificial wound model rats and young healthy hybrid canine. The effects of test drugs on nutritional situations of test animals were discussed to evaluate the clinic nutritional efficacy. [Method] 24 healthy rats and 16 young healthy hybrid canine were randomly divided into test group and control group. Rats in test group and young canine in test group were administrated with the test drug to detect the content changes of plasma TP,ALB and Hb before and after drug administration. 45 healthy rats after artificial wound modeling were divided into 3 groups (low-dose test group, medium-dose test group and control group). Rats in test groups were administrated with different dose of test drug. And the content changes of TP, ALB, SOD and NO in the plasma after operation 3, 7 and 14 days were determined. [Result]①After healthy rats were administrated with test drug, the contents of TP and ALB in the plasma of healthy rats in test group were significantly increased than that in control group(P<0.05).②After healthy young hybrid canine were administrated with test drug three days, the content of TP and Hb in the plasma of healthy young hybrid canine in test group were extremely significantly increased than control group(P<0.01), and ALB content was significantly increased(P<0.05).③After artificial wound model rats were administrated with test drug, the contents of TP, ALB and NO in the plasma in test groups were increased after operation 3 days. After operation 7 days, the contents of TP, ALB and NO in the plasma were extremely significantly increased in medium-dose test group (P<0.01) and significantly increased in low-dose test group (P<0.05). After operation 14 days, the contents of TP and ALB in the plasma in test groups recovered to the level before operation, NO content in the plasma in test groups increased, but there was no significant difference (P>0.05). Compared with control group, SOD content in the plasma in test groups increased after operation 3 and 7 days, but there was no significant difference (P>0.05). After operation 14 days, SOD content in the plasma in test groups increased and SOD content in medium-dose group was significantly increased(P<0.05). [Conclusion] Sheep placental transfer factor could significantly improve the nutritional situations of healthy rats and healthy young hybrid canine, promote the wound recovery of rats after operation and the growth and development of young canine and enhance the disease resistance. And SPTF had the roles of improving the nutrition and enhancing the immunity.
