CAJ | 학술논문

目的：采用嗅觉功能MRI评价血管性痴呆(vascular dementia，VaD)患者的嗅觉功能损害情况。材料与方法15例正常老年人(NC)和12例VaD患者进行MMSE、MOCA、CDR及Hachinski缺血指数量表(HIS)评分，采用西门子3.0 T MR扫描仪、32通道头线圈行嗅觉fMRI扫描，采用Matlab 7.11.0及SPM 8软件处理数据，NC和VaD两组进行独立样本t检验分析。结果 NC和VaD两组之间组分析结果显示，NC组(28簇，共1486个激活体素)激活明显多于VaD组(13簇，共149个激活体素)，激活区域主要位于额叶、颞叶及中央前回等区域。结论 VaD患者存在嗅觉损害，嗅觉fMRI可以评价VaD患者的嗅觉功能，对进一步嗅觉损害的神经退行性疾病研究具有重要价值。
목적：채용후각공능MRI평개혈관성치태(vascular dementia，VaD)환자적후각공능손해정황。재료여방법15례정상노년인(NC)화12례VaD환자진행MMSE、MOCA、CDR급Hachinski결혈지수량표(HIS)평분，채용서문자3.0 T MR소묘의、32통도두선권행후각fMRI소묘，채용Matlab 7.11.0급SPM 8연건처리수거，NC화VaD량조진행독립양본t검험분석。결과 NC화VaD량조지간조분석결과현시，NC조(28족，공1486개격활체소)격활명현다우VaD조(13족，공149개격활체소)，격활구역주요위우액협、섭협급중앙전회등구역。결론 VaD환자존재후각손해，후각fMRI가이평개VaD환자적후각공능，대진일보후각손해적신경퇴행성질병연구구유중요개치。
Objective:The olfactory functional MRI (fMRI) was used to investigate the olfactory deficiency in the vascular dementia (VaD). Materials and Methods:15 normal elderly people (NC group) and 12 VaD (VaD group) patients underwent MMSE, MOCA, CDR and Hachinsk grades. All subjects were scanned by Siemens 3.0 T MRI scanner, with 32 channel head coil, all olfactory fMRI data were processed with 64 bit Matlab 7.11.0 and SPM8 softwares. The independent samples t-test was used to analyze these two groups. Results:Inter-group analysis between two samples showed that the activated voxels in the whole brain of NC group were signiifcantly higher than the VaD group, the activated area was mainly located in the frontal lobe, temporal lobe and the medial frontal gyrus. Conclusion:The VaD patients also suffered olfactory deifcit, the olfactory fMRI can evaluate the olfactory function of VaD patients, which is a potential method to the study of the neurodegenerative diseases with olfactory deifcit.