东南大学学报（医学版）
東南大學學報（醫學版）
동남대학학보（의학판）
JOURNAL OF SOUTHEAST UNIVERSITY(MEDICAL SCIENCE EDITION)
2014年
3期
311-318
,共8页
导管消融%心房大小%心房容积%心房功能%心房颤动
導管消融%心房大小%心房容積%心房功能%心房顫動
도관소융%심방대소%심방용적%심방공능%심방전동
catheter ablation%atrial size%atrial volume%atrial function%atrial fibrillation
目的：通过文献回顾来评价射频消融术对房颤患者左心房大小、容积及功能的影响。方法：计算机检索MEDLINE、EMBASE、ScienceDirct、Highwire、Cochrane 图书馆临床随机对照试验资料库（2000年1月至2012年12月）中评价射频消融术对左心房大小、容积或功能影响的随机对照研究，按照标准筛查文献，提取资料，采用Review Manager 4．2．9对数据进行Meta分析。结果：共纳入26项研究，均为英文，共1821例患者。结果表明，射频消融术后左心房直径及容积较术前降低，但是左心房射血分数/左心房主动排空指数较术前未见明显降低。在亚组分析时我们发现左心房直径及容积的降低在房颤未复发组较复发组明显，而左心房射血分数/左心房主动排空指数在未复发组及复发组均未见明显降低。结论：成功的射频消融术可以降低房颤患者左心房的直径和容积，且不影响左心房功能。
目的：通過文獻迴顧來評價射頻消融術對房顫患者左心房大小、容積及功能的影響。方法：計算機檢索MEDLINE、EMBASE、ScienceDirct、Highwire、Cochrane 圖書館臨床隨機對照試驗資料庫（2000年1月至2012年12月）中評價射頻消融術對左心房大小、容積或功能影響的隨機對照研究，按照標準篩查文獻，提取資料，採用Review Manager 4．2．9對數據進行Meta分析。結果：共納入26項研究，均為英文，共1821例患者。結果錶明，射頻消融術後左心房直徑及容積較術前降低，但是左心房射血分數/左心房主動排空指數較術前未見明顯降低。在亞組分析時我們髮現左心房直徑及容積的降低在房顫未複髮組較複髮組明顯，而左心房射血分數/左心房主動排空指數在未複髮組及複髮組均未見明顯降低。結論：成功的射頻消融術可以降低房顫患者左心房的直徑和容積，且不影響左心房功能。
목적：통과문헌회고래평개사빈소융술대방전환자좌심방대소、용적급공능적영향。방법：계산궤검색MEDLINE、EMBASE、ScienceDirct、Highwire、Cochrane 도서관림상수궤대조시험자료고（2000년1월지2012년12월）중평개사빈소융술대좌심방대소、용적혹공능영향적수궤대조연구，안조표준사사문헌，제취자료，채용Review Manager 4．2．9대수거진행Meta분석。결과：공납입26항연구，균위영문，공1821례환자。결과표명，사빈소융술후좌심방직경급용적교술전강저，단시좌심방사혈분수/좌심방주동배공지수교술전미견명현강저。재아조분석시아문발현좌심방직경급용적적강저재방전미복발조교복발조명현，이좌심방사혈분수/좌심방주동배공지수재미복발조급복발조균미견명현강저。결론：성공적사빈소융술가이강저방전환자좌심방적직경화용적，차불영향좌심방공능。
Objective: To systematically review the effect of radiofrequency catheter ablation ( RFCA ) on left atrial (LA) size, volumes and function in patients with atrial fibrillation (AF).Methods: We searched MEDLINE, EMBASE, ScienceDirct , Highwire , Cochrane Central Register of Controlled Trials , Cochrane database of systematic reviews and the reference lists of retrieved reports in July 2012 .Studies conducted in patients with AF were included if the primary outcomes of the researches were changes of LA size or volumes and /or function after RFCA .Mean differences for changes of LA diameter (LAD),LA maximum volume(LAVmax),LA minimum volume(LAVmin), LA ejection fraction ( LAEF ) , LA active emptying fraction ( LAAEF ) and LA strain were estimated using fixed-effects and random-effects Meta-analyses.Results:Twenty six studies (enrolling 1 821 patients) were included in the final analysis .Compared to preablation values , there were significant decreases in LA diameter and LA volumes at postablation follow-up.However, compared to preablation values , there was no significant differences in LA ejection fraction/LA active emptying fraction and LA strain at postablation follow-up.Decreases in LA diameter and LA volumes remained significant in those without AF recurrence but not in those with AF recurrence .LA ejection fraction/LA active emptying fraction did not decrease in patients without AF recurrence , whereas they decreased in patients with AF recurrence .As for LA strain, it seemed that LA strain increased in patients without AF recurrence , with less fibrosis and with more LA volumes decrease , but the differences was not significant . Conclusion:Successful RFCA in patients with AF significantly decreases LA size and volumes , and does not seem to adversely affect LA function .
