CAJ | 학술논문

免疫治疗是一种颇有前景的抗肿瘤策略。然而，肿瘤中的免疫抑制微环境阻碍了免疫治疗的发展。异常肿瘤血管造成的缺氧，使免疫细胞趋向免疫抑制。并且异常血管通过分泌生长因子及细胞因子，改变免疫细胞的增殖、分化及功能，最终形成免疫抑制的微环境。因此，有效的利用血管生成及肿瘤免疫之间的相互作用，适当的抑制血管形成，促进肿瘤血管正常化，可以改变肿瘤的免疫抑制微环境，成为改善免疫治疗的新策略。现就血管正常化与肿瘤免疫的关系，及二者的联合治疗进行综述。。
면역치료시일충파유전경적항종류책략。연이，종류중적면역억제미배경조애료면역치료적발전。이상종류혈관조성적결양，사면역세포추향면역억제。병차이상혈관통과분비생장인자급세포인자，개변면역세포적증식、분화급공능，최종형성면역억제적미배경。인차，유효적이용혈관생성급종류면역지간적상호작용，괄당적억제혈관형성，촉진종류혈관정상화，가이개변종류적면역억제미배경，성위개선면역치료적신책략。현취혈관정상화여종류면역적관계，급이자적연합치료진행종술。。
Immunotherapies, as a promising anticancer therapy stratrgy, has been paid more and more attentions. However, the abnormal tumor vasculature creates a hypoxic microenvironment that make immune cells toward immune sup-pression. hTe immunosuppressive microenvironment seems to impede the development of immunotherapies. Hence, normal-ization tumor vascular by anti-angiogenesis properly could improve the immunosuppressive miroenvironment. Consequently, the effcacy of the immunotherapies was enhanced. Here, we discuss the effects of vascular normalizing on tumor immunity and propose a potentially strategy to re-engineer the tumor-immune microenvironment and improve cancer immunotherapy.