CAJ | 학술논문

肺癌是我国近年来发病率最高的恶性肿瘤之一，肿瘤低氧首先在肺癌中被发现，低氧与肿瘤细胞的耐药、凋亡、迁徙、血管生成等有密切联系。化疗耐药是肺癌治疗失败、病情进展的重要原因之一，近年来相关研究较多，现对肺癌低氧微环境以及其诱导化疗耐药作用机制的研究进展进行综述。
폐암시아국근년래발병솔최고적악성종류지일，종류저양수선재폐암중피발현，저양여종류세포적내약、조망、천사、혈관생성등유밀절련계。화료내약시폐암치료실패、병정진전적중요원인지일，근년래상관연구교다，현대폐암저양미배경이급기유도화료내약작용궤제적연구진전진행종술。
Lung cancer is one of the malignant tumors with highest incidence recently in our country. Tumor hypoxia phenomenon was ifrst discovered in lung cancer. It plays important roles in tumor cell drug-resistance, apoptosis, inva-sion and metastasis, angiogenesis. Chemotherapy-resistant is one of the core reasons of treatment failure and disease progress, and many works on the study of chemotherapy-resistant have been done. hTis article reviewed the research progress of those mechanisms by which lung cancer hypoxia microenvironment could induce chemotherapy-resistance.