CAJ | 학술논문

目的：探讨血浆氨基末端脑利钠肽前体（NT-proBNP）下降率对慢性心力衰竭（CHF）患者疗效及预后的评估价值。方法连续入选2011年10月至2012年6月在包头市中心医院心内科住院心功能（NYHA分级）Ⅲ～Ⅳ级的CHF患者120例，根据血浆NT-proBNP下降率分为两组，其中A组64例（血浆NT-pro BNP下降率≥50%）；B组56例（血浆NT-proBNP下降率＜50%）。比较两组患者的一般临床资料（包括年龄、性别、体重指数，合并症有无高血压病、糖尿病、高脂血症）、出院时疗效及在出院后6个月内再住院率及死亡率。结果两组患者在出院时疗效评估，A组患者治疗效果良好比例为87.5%，显著高于B组患者（71.4%），差异有统计学意义（P＜0.05）。两组患者出院后随访6个月时，A组患者再住院率为6.3%，显著低于B组患者再住院率（21.4%）；A组患者死亡率为1.6%，显著低于B组患者死亡率（12.5%），差异均有统计学意义（P＜0.05）。结论NT-proBNP的下降率对判断慢性心力衰竭患者的住院治疗效果及预后有帮助。
목적：탐토혈장안기말단뇌리납태전체（NT-proBNP）하강솔대만성심력쇠갈（CHF）환자료효급예후적평고개치。방법련속입선2011년10월지2012년6월재포두시중심의원심내과주원심공능（NYHA분급）Ⅲ～Ⅳ급적CHF환자120례，근거혈장NT-proBNP하강솔분위량조，기중A조64례（혈장NT-pro BNP하강솔≥50%）；B조56례（혈장NT-proBNP하강솔＜50%）。비교량조환자적일반림상자료（포괄년령、성별、체중지수，합병증유무고혈압병、당뇨병、고지혈증）、출원시료효급재출원후6개월내재주원솔급사망솔。결과량조환자재출원시료효평고，A조환자치료효과량호비례위87.5%，현저고우B조환자（71.4%），차이유통계학의의（P＜0.05）。량조환자출원후수방6개월시，A조환자재주원솔위6.3%，현저저우B조환자재주원솔（21.4%）；A조환자사망솔위1.6%，현저저우B조환자사망솔（12.5%），차이균유통계학의의（P＜0.05）。결론NT-proBNP적하강솔대판단만성심력쇠갈환자적주원치료효과급예후유방조。
Objective To investigate the evaluation value of plasma NT-proBNP descent rate to curative effect and prognosis in patients with chronic heart failure (CHF). Methods CHF patients (n=120) with NYHA grading from grade III to grade IV of were chosen from the Central Hospital of Baotou City from Oct. 2011 to Jun. 2012, and then divided into group A (n=64, NT-proBNP descent rate≥50%) and group B (n=56, NT-proBNP descent rate<50%) according to NT-proBNP descent rate. The general data [age, sex, body mass index (BMI), and complications (hypertension, diabetes and hyperlipidemia)], curative effect at discharge time, and readmission and mortality after discharge for 6 months were compared between 2 groups. Results The effective rate was 87.5%in group A and 71.4%in group B (P<0.05) at discharge time. The readmission rate was 6.3%in group A and 21.4%in group B, and mortality was 1.6%in group A and 12.5%in group B (P<0.05) after discharge for 6 months. Conclusion NT-proBNP descent rate is helpful to judge the curative effect and prognosis for hospitalized CHF patients.