CAJ | 학술논문

目的：观察不同剂量造影剂对冠状动脉造影患者肾功能的影响。方法入选2009年12月～2012年7月住院治疗并接受冠脉造影检查与治疗的冠心病患者234例，根据患者在术中使用对比剂剂量的不同将患者分为低剂量组（剂量＜200ml，n=127）和高剂量组（剂量≥200ml，n=107），比较两组患者术前、术后1d、术后7d肾功能相关指标血尿素氮（BUN）、血肌酐（sCr）、尿β2微球蛋白（尿β2MG）变化情况。结果低剂量组及高剂量组患者术后第1天，sCr、BUN、尿β2MG水平较术前显著上升，与治疗前相比，差异具有统计学意义（P＜0.05）；术后第7天，sCr、BUN、尿β2MG水平较术后第1天有显著回落。术后第1天、第7天高剂量与低剂量组患者sCr、BUN、尿β2MG水平比较，差异具有统计学意义（P＜0.05）。结论冠脉造影可促进患者肾功能损害，随着剂量增加，其损害可能越重。
목적：관찰불동제량조영제대관상동맥조영환자신공능적영향。방법입선2009년12월～2012년7월주원치료병접수관맥조영검사여치료적관심병환자234례，근거환자재술중사용대비제제량적불동장환자분위저제량조（제량＜200ml，n=127）화고제량조（제량≥200ml，n=107），비교량조환자술전、술후1d、술후7d신공능상관지표혈뇨소담（BUN）、혈기항（sCr）、뇨β2미구단백（뇨β2MG）변화정황。결과저제량조급고제량조환자술후제1천，sCr、BUN、뇨β2MG수평교술전현저상승，여치료전상비，차이구유통계학의의（P＜0.05）；술후제7천，sCr、BUN、뇨β2MG수평교술후제1천유현저회락。술후제1천、제7천고제량여저제량조환자sCr、BUN、뇨β2MG수평비교，차이구유통계학의의（P＜0.05）。결론관맥조영가촉진환자신공능손해，수착제량증가，기손해가능월중。
Objective To observe the influence of contrast agent in different doses on renal function in patients with coronary arteriography (CAG). Methods The CHD patients (n=234) with CAG were chosen from Dec. 2009 to Jul. 2012, and divided into low-dose group (contrast agent dose<200 mL, n=127) and high-dose group (dose≥200 mL, n=107). The changes of BUN, SCr and urinaryβ2MG were compared between 2 group before CAG and 1 d and 7 d after CAG. Results The levels of SCr, BUN and urinaryβ2MG increased significantly in 2 groups 1 d after CAG (P<0.05), and fall back significantly 7 d after CAG. The comparison in levels of SCr, BUN and urinaryβ2MG showed statistical difference between 2 groups respectively 1 d and 7 d after CAG (P<0.05). Conclusion CAG can induce the damage of renal function and the severity of the damage will be exacerbated as contrast agent dose is increased.