中国循证心血管医学杂志
中國循證心血管醫學雜誌
중국순증심혈관의학잡지
CHINESE JOURNAL OF EVIDENCE-BASES CARDIOVASCULAR MEDICINE
2014年
2期
168-171
,共4页
孙玉青%骆雷鸣%王瑞英%秦爱梅
孫玉青%駱雷鳴%王瑞英%秦愛梅
손옥청%락뢰명%왕서영%진애매
老年男性%非杓型高血压%糖尿病
老年男性%非杓型高血壓%糖尿病
노년남성%비표형고혈압%당뇨병
Aged men%Non-dipper hypertension%Diabetes
目的:探讨老年男性非杓型高血压合并糖尿病对血压昼夜节律形态及心、肾靶器官损害的影响。方法入选老年男性原发性非杓型高血压患者656例,根据是否合并2型糖尿病,分为合并糖尿病组(n=366)与非糖尿病组(n=290)。采用全自动生化分析仪测定空腹血糖(FBG),总胆固醇(TC),甘油三酯(TG),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),氨基末端脑利钠肽前体(NT-proBNP),肌钙蛋白T(TnT),并依据MDRD公式计算肾小球滤过率(eGFR);行心脏超声检查,计算左室质量指数(LVMI)。分析两组患者上述指标差别。结果与非糖尿病组比较,合并糖尿病组患者血红蛋白[(132.3±15.62)mmol/L vs.(131.14±12.32)mmol/L]、TG[(1.52±1.09) mmol/L vs.(1.35±0.69)mmol/L]、HDL-C[(1.15±0.32)mmol/L vs.(1.20±0.33)mmol/L]、T3[(4.05±0.69)nmol/L vs.(4.27±0.85)nmol/L]、TnT[(0.05±0.18)μg/L vs.(0.02±0.02)μg/L]、LVMI [(179.82±44.83)g/m2 vs.(168.21±32.16)g/m2]、24h收缩压[(125.00±12.14)mmHg vs.(123.00±11.11)mmHg]、白昼收缩压[(127.00±13.09)mmHg vs.(125.30±12.29)mmHg]、夜间收缩压[(128.12±16.28) mmHg vs.(125.34±14.59)mmHg]、夜间血压与白天血压比值[(0.99±0.05)mmHg vs.(0.98±0.04)mmHg]有统计学意义(P均<0.05)。结论老年男性原发性非杓型高血压合并糖尿病患者收缩压升高更为严重,血压昼夜节律消失更为明显,心功能损害加重。
目的:探討老年男性非杓型高血壓閤併糖尿病對血壓晝夜節律形態及心、腎靶器官損害的影響。方法入選老年男性原髮性非杓型高血壓患者656例,根據是否閤併2型糖尿病,分為閤併糖尿病組(n=366)與非糖尿病組(n=290)。採用全自動生化分析儀測定空腹血糖(FBG),總膽固醇(TC),甘油三酯(TG),低密度脂蛋白膽固醇(LDL-C),高密度脂蛋白膽固醇(HDL-C),氨基末耑腦利鈉肽前體(NT-proBNP),肌鈣蛋白T(TnT),併依據MDRD公式計算腎小毬濾過率(eGFR);行心髒超聲檢查,計算左室質量指數(LVMI)。分析兩組患者上述指標差彆。結果與非糖尿病組比較,閤併糖尿病組患者血紅蛋白[(132.3±15.62)mmol/L vs.(131.14±12.32)mmol/L]、TG[(1.52±1.09) mmol/L vs.(1.35±0.69)mmol/L]、HDL-C[(1.15±0.32)mmol/L vs.(1.20±0.33)mmol/L]、T3[(4.05±0.69)nmol/L vs.(4.27±0.85)nmol/L]、TnT[(0.05±0.18)μg/L vs.(0.02±0.02)μg/L]、LVMI [(179.82±44.83)g/m2 vs.(168.21±32.16)g/m2]、24h收縮壓[(125.00±12.14)mmHg vs.(123.00±11.11)mmHg]、白晝收縮壓[(127.00±13.09)mmHg vs.(125.30±12.29)mmHg]、夜間收縮壓[(128.12±16.28) mmHg vs.(125.34±14.59)mmHg]、夜間血壓與白天血壓比值[(0.99±0.05)mmHg vs.(0.98±0.04)mmHg]有統計學意義(P均<0.05)。結論老年男性原髮性非杓型高血壓閤併糖尿病患者收縮壓升高更為嚴重,血壓晝夜節律消失更為明顯,心功能損害加重。
목적:탐토노년남성비표형고혈압합병당뇨병대혈압주야절률형태급심、신파기관손해적영향。방법입선노년남성원발성비표형고혈압환자656례,근거시부합병2형당뇨병,분위합병당뇨병조(n=366)여비당뇨병조(n=290)。채용전자동생화분석의측정공복혈당(FBG),총담고순(TC),감유삼지(TG),저밀도지단백담고순(LDL-C),고밀도지단백담고순(HDL-C),안기말단뇌리납태전체(NT-proBNP),기개단백T(TnT),병의거MDRD공식계산신소구려과솔(eGFR);행심장초성검사,계산좌실질량지수(LVMI)。분석량조환자상술지표차별。결과여비당뇨병조비교,합병당뇨병조환자혈홍단백[(132.3±15.62)mmol/L vs.(131.14±12.32)mmol/L]、TG[(1.52±1.09) mmol/L vs.(1.35±0.69)mmol/L]、HDL-C[(1.15±0.32)mmol/L vs.(1.20±0.33)mmol/L]、T3[(4.05±0.69)nmol/L vs.(4.27±0.85)nmol/L]、TnT[(0.05±0.18)μg/L vs.(0.02±0.02)μg/L]、LVMI [(179.82±44.83)g/m2 vs.(168.21±32.16)g/m2]、24h수축압[(125.00±12.14)mmHg vs.(123.00±11.11)mmHg]、백주수축압[(127.00±13.09)mmHg vs.(125.30±12.29)mmHg]、야간수축압[(128.12±16.28) mmHg vs.(125.34±14.59)mmHg]、야간혈압여백천혈압비치[(0.99±0.05)mmHg vs.(0.98±0.04)mmHg]유통계학의의(P균<0.05)。결론노년남성원발성비표형고혈압합병당뇨병환자수축압승고경위엄중,혈압주야절률소실경위명현,심공능손해가중。
Objective To investigate the influences of non-dipper hypertension complicating diabetes on circadian rhythm of blood pressure and target organ damage in male elderly patients. Methods The patients (n=656) were chosen and divided into diabetes group (n=366) and non-diabetes group (n=290) according to whether they had complicating diabetes or not. The changes of FBG, TC, TG, LDL-C, HDL-C, NT-proBNP and TnT were detected by using automatic biochemical analyzer, and eGFR was calculated according to MDRD formula. The patients were given cardiac ultrasound examinations for computing LVMI. The difference in all above indexes was analyzed in 2 groups. Results The difference in the levels of Hb [(132.3±15.62) mmol/L vs. (131.14±12.32) mmol/L], TG [(1.52 ±1.09) mmol/L vs. (1.35±0.69) mmol/L], HDL-C [(1.15±0.32) mmol/L vs. (1.20±0.33) mmol/L], T3 [(4.05±0.69) nmol/L vs. (4.27±0.85) nmol/L], TnT [(0.05±0.18)μg/L vs. (0.02±0.02)μg/L], LVMI [(179.82±44.83) g/m2 vs. (168.21±32.16) g/m2], 24-h SBP [(125.00±12.14) mmHg vs. (123.00±11.11) mmHg], daytime SBP [(127.00 ±13.09) mmHg vs. (125.30±12.29) mmHg], nighttime SBP [(128.12±16.28) mmHg vs. (125.34±14.59) mmHg], and ratio of daytime SBP to nighttime SBP [(0.99±0.05) mmHg vs. (0.98±0.04) mmHg] had statistical significance compared between 2 groups (all P<0.05). Conclusion The increase of SBP is more serious, disappearance of circadian rhythm is more obvious, and heart function damage is more exacerbated in male elderly patients with non-dipper hypertension complicating diabetes.