CAJ | 학술논문

人类微生物组计划Ⅰ期已经结束，作为该项目子项目之一的口腔微生物组项目，已经获得了海量的测序数据。本文综述了口腔微生物组（包括细菌、真菌、病毒和古细菌）的组成及多样性；通过分析患有特定疾病如龋病、牙周病、全身系统性疾病志愿者的口腔微生物组成，解析口腔微生物群落结构变化与疾病之间的相互联系。
인류미생물조계화Ⅰ기이경결속，작위해항목자항목지일적구강미생물조항목，이경획득료해량적측서수거。본문종술료구강미생물조（포괄세균、진균、병독화고세균）적조성급다양성；통과분석환유특정질병여우병、아주병、전신계통성질병지원자적구강미생물조성，해석구강미생물군락결구변화여질병지간적상호련계。
Human microbiome project(HMP) phase Ⅰ have been completed last year and a slew of genetic sequences have obtained from human oral microbiome project, a sub-project of HMP. This review summarized the extensive oral microbiome composition and diversity, including bacteria, fungi, virus and archae. By analyzing the microbiota of clinical samples collected from patient suffering from diseases such as caries, periodontal diseases and systematic diseases, the relationship between oral microbial shifts and human diseases was investigated.