CAJ | 학술논문

目的：观察中医益气生血法对中晚期鼻咽癌放化疗疗效及不良反应的影响。方法：68例初治中晚期鼻咽癌患者随机分为2组，观察组（中药联合放化疗组）35例，对照组（放化疗组）33例。两组均采用常规放疗同期行PF方案化疗。观察组从放疗开始联合使用益气生血类中药直至放疗结束。比较两组病人在治疗期间肿瘤消退情况、血红蛋白改善情况、放疗急性反应等。结果：观察组的肿瘤缓解率（PR＋CR）高于对照组分别为91．4％（32/35）和84．8％（28/33），但无统计学上的显著差异（P＝0．471）；观察组血红蛋白显著升高（P＜0．001）；观察组乏力发生率明显少于对照组（P＜0．001）。结论：益气生血法对同步放化疗短期疗效无明显影响，但可减轻放化疗毒副反应，提高生活质量。
목적：관찰중의익기생혈법대중만기비인암방화료료효급불량반응적영향。방법：68례초치중만기비인암환자수궤분위2조，관찰조（중약연합방화료조）35례，대조조（방화료조）33례。량조균채용상규방료동기행PF방안화료。관찰조종방료개시연합사용익기생혈류중약직지방료결속。비교량조병인재치료기간종류소퇴정황、혈홍단백개선정황、방료급성반응등。결과：관찰조적종류완해솔（PR＋CR）고우대조조분별위91．4％（32/35）화84．8％（28/33），단무통계학상적현저차이（P＝0．471）；관찰조혈홍단백현저승고（P＜0．001）；관찰조핍력발생솔명현소우대조조（P＜0．001）。결론：익기생혈법대동보방화료단기료효무명현영향，단가감경방화료독부반응，제고생활질량。
Objective:To investigate the efficacy and safety of Yiqi Shengxue Soup combined with concurrent chemoradiation in locally advanced nasopharyngeal cancer patients .Methods: Eligible patients with no prior chemoradiation were randomly assigned to receive concurrent chemoradiation ( regular radiation with DDP plus 5-FU) with or without Yiqi Shengxue Soup .The primary endpoint was objective response rate and secondary endpoint was the incidence of adverse events .Results:68 patients, 35 in concurrent chemoradi-ation with Yiqi Shengxue Soup group ( combination group ) and 33 in concurrent chemoradiation alone group ( control group ) were re-cruited.The objective response rate ( PR+CR) was numerically but not statistically higher in combination group than in control group (91.4%VS 84.8%, P=0.471).The absolute value of hemoglobin at the end of treatment was significantly higher in combination group (110.06 ±6.17 vs 90.70 ±5.48, P<0.001).The incidence of grade3/4 fatigue was significantly lower in combination group (2.9%vs 30.3%, P<0.001).Conclusion:Yiqi Shengxue Soup reduced the incidence of anemia and acute radiation effect of con -current chemoradiation and improved the quality of life in locally advanced nasopharyngeal cancer patients .