CAJ | 학술논문

已有随机对照临床试验证实粪菌移植治疗肠道艰难梭菌感染具有很好的疗效。尽管目前尚缺乏高质量的证据支持，粪菌移植已逐渐应用于治疗其他肠道微生态失调的疾病，譬如炎症性肠病（IBD）。该文追溯粪菌移植的起源、阐述粪菌移植的研究现状、介绍粪菌移植的实施方案、讨论粪菌移植治疗 IBD 的有效性以及分析粪菌移植治疗 IBD 的可行性。目前粪菌移植广泛用于临床仍存在一些问题，但粪菌移植治疗 IBD 非常具有前景，值得重视该研究领域。
이유수궤대조림상시험증실분균이식치료장도간난사균감염구유흔호적료효。진관목전상결핍고질량적증거지지，분균이식이축점응용우치료기타장도미생태실조적질병，비여염증성장병（IBD）。해문추소분균이식적기원、천술분균이식적연구현상、개소분균이식적실시방안、토론분균이식치료 IBD 적유효성이급분석분균이식치료 IBD 적가행성。목전분균이식엄범용우림상잉존재일사문제，단분균이식치료 IBD 비상구유전경，치득중시해연구영역。
Randomized controlled clinical trial demonstrated that fecal microbiota transplantation (FMT)has a high efficacy in treating intestinal infection by Clostridium difficile.Although highly convincing evidence is still lacking currently,FMT has been increasingly applied in treatment of alternative diseases relat-ed to gastrointestinal dysbiosis,such as inflammatory bowel disease (IBD).The purpose of this review is to verify the origin of FMT,describe current situation of FMT,introduce practical protocol of FMT,discuss the efficacy of FMT in treatment of IBD and analyze the feasibility of FMT in treating IBD.Albeit the application of FMT still has certain problems in clinical settings,FMT is a promising option to treat IBD and deserves more attention to this field.