CAJ | 학술논문

目的：分析不同方法治疗膝关节骨性关节炎对患者尿CTX-Ⅱ、COMP、PYD的影响，以提高治疗膝关节骨性关节炎的安全性。方法选取2011年3月~2013年2月我院膝关节骨性关节炎患者84例作为实验对象，使用计算机随机的方法分为三组。第一组患者使用曲安奈德膝关节注射，第二组患者使用玻璃酸钠膝关节注射治疗，第三组患者使用曲安奈德联合玻璃酸钠膝关节内注射治疗，比较三组患者治疗效果和治疗前后尿CTX-Ⅱ、COMP、PYD水平。结果混合组患者治疗3个月后，其WOMAC评分明显低于曲安奈德组、玻璃酸钠组，两组比较，差异有统计意义（P＜0.05）。混合组患者治疗后，其尿CTX-Ⅱ、COMP、PYD改善效果更明显，与其他两组比较，差异有统计学意义（P＜0.05）。结论使用曲安奈德联合玻璃酸钠联合膝关节注射可以更好地治疗膝关节骨性关节炎患者的治疗效果，通过尿CTX-Ⅱ、COMP、PYD可以判断患者的预后。
목적：분석불동방법치료슬관절골성관절염대환자뇨CTX-Ⅱ、COMP、PYD적영향，이제고치료슬관절골성관절염적안전성。방법선취2011년3월~2013년2월아원슬관절골성관절염환자84례작위실험대상，사용계산궤수궤적방법분위삼조。제일조환자사용곡안내덕슬관절주사，제이조환자사용파리산납슬관절주사치료，제삼조환자사용곡안내덕연합파리산납슬관절내주사치료，비교삼조환자치료효과화치료전후뇨CTX-Ⅱ、COMP、PYD수평。결과혼합조환자치료3개월후，기WOMAC평분명현저우곡안내덕조、파리산납조，량조비교，차이유통계의의（P＜0.05）。혼합조환자치료후，기뇨CTX-Ⅱ、COMP、PYD개선효과경명현，여기타량조비교，차이유통계학의의（P＜0.05）。결론사용곡안내덕연합파리산납연합슬관절주사가이경호지치료슬관절골성관절염환자적치료효과，통과뇨CTX-Ⅱ、COMP、PYD가이판단환자적예후。
Objective To analyze and study the effect of different treatment methods on urinary CTX-Ⅱ, COMP, PYD in patients with osteoarthritis of knee, in order to improve the treatment security of osteoarthritis of knee. Methods 84 patients with osteoarthritis of knee from March 2011 to February 2013 in our hospital were as the experimental subjects, who were divided into the three groups by using the computer random method. The patients in the first group were treated with the knee injection of triamcinolone acetonide, the patients in the second group were treated with the knee injection of sodium hyaluronate, and the patients in the third group were treated with the knee injection of sodium hyaluronate combined with triamcinolone acetonide, and the treatment effect and urinary CTX-Ⅱ, COMP, PYD levels of patients in the three groups before and after treatment were observed and compared. Results The WOMAC score of patients in the mixed group after 3 months of treatment was significantly lower than that in the triamcinolone acetonide group or the sodium hyaluronate group, the difference was statistically significant between the two groups(P<0.05). Compared with the other two groups, the effect of urinary CTX-Ⅱ, COMP, PYD of patients in the mixed group after treatment improved more obviously,the difference was statistically significant (P<0.05). Conclusion The knee injection of sodium hyaluronate combined with triamcinolone acetonide can better treat the patients with osteoarthritis of knee, and the urinary CTX-Ⅱ, COMP, PYD can determine the prognosis of patients.