CAJ | 학술논문

目的：分析焦虑症患者临床治愈前后脑血流调节的变化。方法应用经颅多普勒超声（transcranial Doppler，TCD）卧-立位脑血流检测方法分析50例焦虑症患者在体位变化时脑血流速度的变化特点并与健康对照组比较，然后随访6个月，观察焦虑症治愈组与未愈组TCD卧-立位脑血流变化。结果焦虑症组较对照组立位时脑血流速度下降（P<0.001），卧-立位脑血流差值大于对照组（P<0.001）；随访发现，焦虑症治愈组治疗后较治疗前卧-立位脑血流差值减小（P<0.001），可恢复到对照组水平；焦虑症未愈组治疗后卧-立位脑血流差值仍大于对照组（P=0.007）；治疗后治愈组卧-立位脑血流差值较未愈组减小（P=0.003）。结论 TCD卧-立位脑血流检测显示，焦虑症患者存在脑血流调节的异常，而且在焦虑症临床治愈后，脑血流调节可恢复正常。
목적：분석초필증환자림상치유전후뇌혈류조절적변화。방법응용경로다보륵초성（transcranial Doppler，TCD）와-립위뇌혈류검측방법분석50례초필증환자재체위변화시뇌혈류속도적변화특점병여건강대조조비교，연후수방6개월，관찰초필증치유조여미유조TCD와-립위뇌혈류변화。결과초필증조교대조조립위시뇌혈류속도하강（P<0.001），와-립위뇌혈류차치대우대조조（P<0.001）；수방발현，초필증치유조치료후교치료전와-립위뇌혈류차치감소（P<0.001），가회복도대조조수평；초필증미유조치료후와-립위뇌혈류차치잉대우대조조（P=0.007）；치료후치유조와-립위뇌혈류차치교미유조감소（P=0.003）。결론 TCD와-립위뇌혈류검측현시，초필증환자존재뇌혈류조절적이상，이차재초필증림상치유후，뇌혈류조절가회복정상。
Objective To study cerebral blood flow regulation features in patients with anxiety before and after treatment. <br> Methods Subjects with Hamilton anxiety scale scores 14 were enrolled, and the dynamic changes in their cerebral blood flow velocity (CBFV) in response to an orthostatic challenge were investigated using transcranial Doppler. Next, we provided the patients with treatment, and then they were followed-up for a period of 6 months. The dynamic changes in their CBFV values were then re-recorded. <br> Results The CBFV changes from supine to upright differed between the anxious and the healthy groups. Anxious subjects showed more pronounced decreases in CBFV with abrupt standing (P<0.001). In the recovery group, the changes in the mean CBFV values from the supine to the upright position were significantly improved after treatment (P<0.001), and can restore to the healthy group level. <br> Conclusion Our results indicate that cerebral blood flow regulation is compromised in anxiety;however, it can restore to normal after the disappearance of anxiety.