CAJ | 학술논문

维生素D是人体必需的一种脂溶性维生素，它通过维生素D受体发挥其主要作用。近10年人们对于维生素D的关注度越来越高。根据流行病学调查，目前全球近10亿人处于维生素D不足或缺乏状态，我国人群维生素D不足现象也较为普遍。由于1，25-羟维生素D半衰期非常短，最近维生素D水平已用血清25-羟维生素D水平来描述。多种证据表明，维生素D缺乏不仅造成骨骼疾病（包括营养性佝偻病、软骨病、骨质疏松），还与多种骨骼外疾病密切相关，包括全因死亡率、心血管疾病及心血管病死亡率、代谢综合征（肥胖、糖耐量减低/糖尿病、脂代谢紊乱、高血压）、恶性肿瘤、感染、过敏性疾病及哮喘、精神及神经疾病、自身免疫性疾病、慢性肾病等。虽然使用维生素D治疗骨骼疾病已经得到广泛认可，但是治疗骨骼外疾病的疗效及远期效果还不明确。维生素D缺乏已成为全世界的公共健康问题。本文综述了近年来对维生素D缺乏相关性疾病的研究进展。
유생소D시인체필수적일충지용성유생소，타통과유생소D수체발휘기주요작용。근10년인문대우유생소D적관주도월래월고。근거류행병학조사，목전전구근10억인처우유생소D불족혹결핍상태，아국인군유생소D불족현상야교위보편。유우1，25-간유생소D반쇠기비상단，최근유생소D수평이용혈청25-간유생소D수평래묘술。다충증거표명，유생소D결핍불부조성골격질병（포괄영양성구루병、연골병、골질소송），환여다충골격외질병밀절상관，포괄전인사망솔、심혈관질병급심혈관병사망솔、대사종합정（비반、당내량감저/당뇨병、지대사문란、고혈압）、악성종류、감염、과민성질병급효천、정신급신경질병、자신면역성질병、만성신병등。수연사용유생소D치료골격질병이경득도엄범인가，단시치료골격외질병적료효급원기효과환불명학。유생소D결핍이성위전세계적공공건강문제。본문종술료근년래대유생소D결핍상관성질병적연구진전。
As an essential fat-soluble vitamin in human body, the main function of vitamin D is mediated by vitamin D receptor.In the past decade, vitamin D has drawn more and more attention.According to epidemiological survey, there are almost one billion people under the state of vitamin D insufficiency or deficiency all over the world.And this phenomenon is very common in China. Because of the short half-life of vitamin D, more recently, the level of serum 25-hydroxyvitamin D has been used to describe the level of vitamin D.Several lines of evidence indicate that the vitamin D deficiency is associated with not only skeletal disorders ( including nutritional rickets, osteomalacla, and osteoporosis ) , but also non-skeletal disorders, such as mortality rate, cardiovascular disorders and mortality, metabolic syndrome ( including obesity, IGT/diabetes mellitus, lipid metabolism disorders, and hypertension) , cancer, infection, allergy and asthma, neurological and mental diseases, autoimmune diseases, and chronic kidney diseases.Although the vitamin D treatment of skeletal disorders has been widely recognized, the efficacy and long-term effect on non-skeletal disorders is not clear.Vitamin D deficiency has become a worldwide public health problem.This article reviews the research progress in vitamin D deficiency-related diseases in recent years.