CAJ | 학술논문

类风湿关节炎（ rheumatoid arthritis ，RA）作为一种自身免疫性疾病，其病理表现为血管翳侵袭性增生破坏滑膜及骨质，与肿瘤的异常增生类似，引起人们对RA发病过程是否有癌基因参与的设想。而骨代谢异常贯穿于RA的整个病程，可以表现为局部骨侵蚀、骨质疏松症（ osteoporosis ，OP）甚至病理性骨折。 p53基因作为发现较早，分布最广的抑癌基因之一，在自身免疫性疾病中的作用也日益受到重视。本文就p53在RA病程及RA骨代谢中可能的作用及机制进行阐述，并提出目前可能存在的一些问题，希望对进一步的研究起到一定的提示作用。
류풍습관절염（ rheumatoid arthritis ，RA）작위일충자신면역성질병，기병리표현위혈관예침습성증생파배활막급골질，여종류적이상증생유사，인기인문대RA발병과정시부유암기인삼여적설상。이골대사이상관천우RA적정개병정，가이표현위국부골침식、골질소송증（ osteoporosis ，OP）심지병이성골절。 p53기인작위발현교조，분포최엄적억암기인지일，재자신면역성질병중적작용야일익수도중시。본문취p53재RA병정급RA골대사중가능적작용급궤제진행천술，병제출목전가능존재적일사문제，희망대진일보적연구기도일정적제시작용。
Rheumatoid arthritis ( RA) is a kind of autoimmune diseases, with the pathological manifestation of invasive hyperplasia of pannus destroying the synovial membrane and the bone, which is similar to the pathologic hyperplasia in tumors.Now more attention has been paid to the possible involvement of oncogenes in RA.The disorder of bone metabolism happens during the whole course of RA, and it could present as local bone erosion, osteoporosis ( OP) , or even pathological fractures.However, p53 gene, the oncogene with early discovery and wild distribution, plays a more and more important role in the autoimmune diseases.In this article, we illustrate the effect and mechanism of p53 in the RA and bone metabolism.We also point out some existed problems, hoping to be useful for the future researches.