CAJ | 학술논문

大量骨质疏松的分子水平研究发现，骨代谢过程中存在受多种调节因子调控的信号通路，如OPG/RANKL/RANKL通路、Wnt/β-catenin通路、组织蛋白酶K通路和骨形成蛋白通路。通过研究上述分子信号通路，明确各信号通路中的重要靶点，通过抑制或促进各靶点蛋白的合成和分泌，达到抑制骨吸收和促进骨形成的目的，从而对骨质疏松症的防治开辟新的方向。
대량골질소송적분자수평연구발현，골대사과정중존재수다충조절인자조공적신호통로，여OPG/RANKL/RANKL통로、Wnt/β-catenin통로、조직단백매K통로화골형성단백통로。통과연구상술분자신호통로，명학각신호통로중적중요파점，통과억제혹촉진각파점단백적합성화분비，체도억제골흡수화촉진골형성적목적，종이대골질소송증적방치개벽신적방향。
Abundant researches of osteoporosis at molecular level reveal that the bone metabolism is regulated by various molecular signal pathways, including OPG/RANKL/RANKL pathway, Wnt/β-catenin pathway, Cathepsin K pathway, and BMP pathway. Through the researches of these signal pathways, we can identify the important target in each signal pathway.By inhibiting or promoting the synthesis and secretion of each target protein, we can inhibit bone resorption and promot bone formation, finally developing a new strategy in the prevention and treatment of osteoporosis.