CAJ | 학술논문

目的：研究维生素D与骨密度的相关性。方法调查248名自由居住在上海的中老年人，女性128名，男性120名，年龄在40到90之间，他们都是从人口基数中随机选入的。分别测量选入对象的全身骨密度和血清中25（ OH） D的含量，分析两者之间的相关性。结果研究对象的平均年龄70.03±11.44岁，其中男性的平均年龄为70.96±12.22岁，女性的平均年龄为69.16±10.62岁。研究对象的平均25（ OH） D的总量浓度为13.733±6.894 ng/ml；平均25（ OH） D2的浓度为1.672±1.577 ng/ml，平均25（OH）D3的浓度为12.057±6.631 ng/ml。其中男性平均25（OH）D的总量浓度为14.258±5.557 ng/ml；平均25（OH）D2的浓度为1.580±1.548 ng/ml，平均25（OH）D3的浓度为12.710±5.440 ng/ml。女性平均25（OH）D的总量浓度为13.241±7.937 ng/ml；平均25（OH）D2的浓度为1.758±1.604 ng/ml，平均25（OH）D3的浓度为11.445±7.550 ng/ml。研究对象中97％（n＝241）25（OH）D的浓度小于30 ng/ml；其中男性中99％的人（n＝119）25（OH）D的浓度小于30 ng/ml；女性中95％的人（n＝122）25（OH）D的浓度小于30 ng/ml。研究对象中83％（n＝206）的人伴有股骨颈骨质疏松；86％的人（n＝214）伴有腰椎的骨质疏松。其中男性中82％的人（n＝98）伴有股骨颈骨质疏松，84.2％的人（n＝101）伴有腰椎的骨质疏松。女性中84.4％的人（n＝108）伴有股骨颈骨质疏松，88.3％的人（n＝113）伴有腰椎的骨质疏松。在多变量的数据分析里，校正了年龄、体重指数的差异后，发现25（OH）D与骨密度之间存在一定关系（见表3、4、5）。结论在中国上海健康中老年人群中存在严重的维生素D不足和缺乏状况，维生素D的状态与骨密度可能存在正性相关，必须进一步进行大样本的研究来探讨维生素D与骨质疏松症及骨折的关系。
목적：연구유생소D여골밀도적상관성。방법조사248명자유거주재상해적중노년인，녀성128명，남성120명，년령재40도90지간，타문도시종인구기수중수궤선입적。분별측량선입대상적전신골밀도화혈청중25（ OH） D적함량，분석량자지간적상관성。결과연구대상적평균년령70.03±11.44세，기중남성적평균년령위70.96±12.22세，녀성적평균년령위69.16±10.62세。연구대상적평균25（ OH） D적총량농도위13.733±6.894 ng/ml；평균25（ OH） D2적농도위1.672±1.577 ng/ml，평균25（OH）D3적농도위12.057±6.631 ng/ml。기중남성평균25（OH）D적총량농도위14.258±5.557 ng/ml；평균25（OH）D2적농도위1.580±1.548 ng/ml，평균25（OH）D3적농도위12.710±5.440 ng/ml。녀성평균25（OH）D적총량농도위13.241±7.937 ng/ml；평균25（OH）D2적농도위1.758±1.604 ng/ml，평균25（OH）D3적농도위11.445±7.550 ng/ml。연구대상중97％（n＝241）25（OH）D적농도소우30 ng/ml；기중남성중99％적인（n＝119）25（OH）D적농도소우30 ng/ml；녀성중95％적인（n＝122）25（OH）D적농도소우30 ng/ml。연구대상중83％（n＝206）적인반유고골경골질소송；86％적인（n＝214）반유요추적골질소송。기중남성중82％적인（n＝98）반유고골경골질소송，84.2％적인（n＝101）반유요추적골질소송。녀성중84.4％적인（n＝108）반유고골경골질소송，88.3％적인（n＝113）반유요추적골질소송。재다변량적수거분석리，교정료년령、체중지수적차이후，발현25（OH）D여골밀도지간존재일정관계（견표3、4、5）。결론재중국상해건강중노년인군중존재엄중적유생소D불족화결핍상황，유생소D적상태여골밀도가능존재정성상관，필수진일보진행대양본적연구래탐토유생소D여골질소송증급골절적관계。
Objective To investigate the correlation between vitamin D and bone mineral density ( BMD) .Methods A total of 248 middle-aged and elder Shanghai residents, including 128 women and 128 men, aged between 40 and 90 years old, were randomly selected from participants of a population-based study.BMD of the whole body and serum 25-( OH ) D level were detected.The correlation between those was analyzed.Results The average age of all the subjects was 70.03 ±11.44 years old, an average age of 70.96 ±12.22 years old in men and 69.16 ±10.62 years old in women.The total concentration of 25-( OH) D in all the subjects was 13.733 ±6.894 ng/ml.The average concentration of 25-( OH) D2 and 25-( OH) D3 in all subjects was 1.672 ± 1.577 ng/ml and 12.057 ±6.631 ng/ml, respectively.In men, the concentration of total 25-( OH) D, 25-( OH) D2 , and 25-( OH) D3 was 14.258 ±5.557 ng/ml, 1.580 ±1.548 ng/ml, and 12.710 ±5.440 ng/ml, respectively.The concentration in women was 13.241 ±7.937 ng/ml, 1.758 ±1.604 ng/ml, and 11.445 ±7.550 ng/ml, respectively.Among all the subjects, 83%(n=206) had femoral neck osteoporosis, and 86% ( n =214 ) had lumbar osteoporosis.In men, 82% ( n =98 ) had femoral neck osteoporosis, and 84.2%(n=101) had lumbar osteoporosis.In women, 84.4% (n=108) had femoral neck osteoporosis, and 88.3% (n=113) had lumbar osteoporosis.After adjusting for age and body mass index difference in multivariate data analysis, 25-( OH) D was correlated with BMD to some extent.Conclusion The insufficiency and deficiency of vitamin D is severe in the healthy elderly population in Shanghai.Vitamin D may be positively correlated with BMD.Further large sample research must be performed to explore the relationship between vitamin D and osteoporosis and the fracture.