CAJ | 학술논문

目的：探讨健康中年男性人体成分对骨密度影响，为男性骨质疏松早期防治提供理论依据。方法以上海市奉贤区128名年龄为40～60岁（平均49.10±6.40岁）的健康中年男性为研究对象，测定其身高、体重、腰围、臀围，并计算体重指数（ BMI）；利用问卷调查调查其文化程度、饮酒吸烟、豆制品及奶制品摄入情况、静坐时间、睡眠时间等一般情况；利用全自动生化分析仪测定血钙（Ca）、血磷（P）、肝肾功能（ALT、AST、BUN、Cr、UA）、血脂（TC、TG、HDL、LDL）、血糖（FPG、2h-PG），高压液相法测定糖化血红蛋白（HbA1c）等生化指标；采用双能X线骨密度仪测定腰椎、股骨颈、股骨干、股骨大粗隆和全身骨密度（ BMD），并根据T值或Z值评分结果将所有研究对象分为骨量正常组和骨量低下组；采用人体成分分析仪测定体脂肪含量、蛋白质含量、无机盐含量、骨骼肌含量和各部位肌肉含量。结果128名年龄为40～60岁健康中年男性中，骨质疏松患者3人，骨量减少患者44人。骨量正常组体重、BMI、腰围、臀围、睡眠时间、蛋白质含量、无机质含量、骨骼肌含量、各部位肌肉含量皆高于骨量低下组，血清尿素及吸烟人数比率低于骨量低下组，且差异具有统计学意义；两组年龄、身高、饮酒情况、文化程度、工作性质、豆制品摄入情况及奶制品摄入情况、Ca、P、Cr、UA、ALT、AST、TC、TG、HDL、LDL、FPG、2h-PG、HbA1c、体脂肪及体脂百分比皆无统计学差异。结论适当延长每天睡眠时间有利于预防骨质疏松的发生；体重、BMI、腰围、臀围是骨质疏松的保护因素，但需通过加强体育锻炼及合理饮食，增加骨骼肌、无机质及蛋白质等非脂肪含量来增加骨密度预防骨质疏松。
목적：탐토건강중년남성인체성분대골밀도영향，위남성골질소송조기방치제공이론의거。방법이상해시봉현구128명년령위40～60세（평균49.10±6.40세）적건강중년남성위연구대상，측정기신고、체중、요위、둔위，병계산체중지수（ BMI）；이용문권조사조사기문화정도、음주흡연、두제품급내제품섭입정황、정좌시간、수면시간등일반정황；이용전자동생화분석의측정혈개（Ca）、혈린（P）、간신공능（ALT、AST、BUN、Cr、UA）、혈지（TC、TG、HDL、LDL）、혈당（FPG、2h-PG），고압액상법측정당화혈홍단백（HbA1c）등생화지표；채용쌍능X선골밀도의측정요추、고골경、고골간、고골대조륭화전신골밀도（ BMD），병근거T치혹Z치평분결과장소유연구대상분위골량정상조화골량저하조；채용인체성분분석의측정체지방함량、단백질함량、무궤염함량、골격기함량화각부위기육함량。결과128명년령위40～60세건강중년남성중，골질소송환자3인，골량감소환자44인。골량정상조체중、BMI、요위、둔위、수면시간、단백질함량、무궤질함량、골격기함량、각부위기육함량개고우골량저하조，혈청뇨소급흡연인수비솔저우골량저하조，차차이구유통계학의의；량조년령、신고、음주정황、문화정도、공작성질、두제품섭입정황급내제품섭입정황、Ca、P、Cr、UA、ALT、AST、TC、TG、HDL、LDL、FPG、2h-PG、HbA1c、체지방급체지백분비개무통계학차이。결론괄당연장매천수면시간유리우예방골질소송적발생；체중、BMI、요위、둔위시골질소송적보호인소，단수통과가강체육단련급합리음식，증가골격기、무궤질급단백질등비지방함량래증가골밀도예방골질소송。
Objective To investigate the effect of body composition on bone mineral density ( BMD ) in healthy middle-aged men, and to provide theoretical basis for the early prevention and treatment of male osteoporosis.Methods One hundred and twenty-eight healthy middle-aged men, aging between 40 and 60 years old, with an average age of 49.10 ±6.40 years old, from Fengxian District in Shanghai were enrolled in this study.The height, weight, waistline, hipline of all the subjects were measured. Body mass index ( BMI) was calculated.The educational background, drinking and smoking history, intake of bean products and milk, sedentary time, hours of sleep were surveyed using a questionnaire.At the same time, blood calcium ( Ca), blood phosphorus ( P) , the indexes of liver and kidney function ( ALT, AST, BUN, Cr, and UA) , blood lipid levels ( TC, TG, HDL, and LDL), blood glucose (FPG, 2h-PG) were detected using automatic biochemical analyzer.The level of HbA1c was detected using high pressure liquid chromatography.The bone mineral density ( BMD) of the lumbar vertebrae, the left proximal femur, the femoral shaft, and the whole bones was detected using dual-energy X-ray absorptiometry.The fat mass, protein mass, mineral salt mass, skeletal muscle mass, and muscle of each segment were measured using human body composition analyzer.Results Among all the subjects, 3 had osteoporosis and 44 had osteopenia.The weight, waistline, hipline, BMI, hours of sleep, fat mass, protein mass, mineral salt mass, skeletal muscle mass, and muscle of each segment in normal group were much higher than those in osteopenia group, and the blood urea and the ratio of smoking were lower than those in osteopenia group (P<0.05).However, no significant difference of age, height, educational background, drinking, intake of bean products and milk, sedentary time, blood Ca, P, Cr, UA, ALT, AST, TC, TG, HDL, LDL, FPG, 2h-PG, and HbA1c, fat mass, and the percentage of body fat was observed between the two groups.Conclusion Properly prolonged sleeping time is beneficial for the prevention of osteoporosis. Weight, BMI, waistline, and hipline are protective factors of BMD.Taking more exercise and proper diet is needed to increase the non-fat mass including skeletal muscle, inorganic substance, and protein, and to increase BMD to prevent osteoporosis.