新疆医科大学学报
新疆醫科大學學報
신강의과대학학보
JOURNAL OF XINJIANG MEDICAL UNIVERSITY
2014年
3期
309-311
,共3页
阿苯达唑%前体胶束%包封率%高效液相色谱法%葡聚糖凝胶法
阿苯達唑%前體膠束%包封率%高效液相色譜法%葡聚糖凝膠法
아분체서%전체효속%포봉솔%고효액상색보법%포취당응효법
albendazole%premicelle%entrapment efficiency%HPLC%sephadex
目的：建立阿苯达唑前体胶束的包封率的测定方法。方法采用葡聚糖凝胶过滤法分离阿苯达唑胶束与游离药物，HPLC 法测定阿苯达唑前体胶束的包封率。结果 HPLC 法测定阿苯达唑前体胶束的包封率为76．38％～81．0％，RSD＝6．81％，回收率为（92．23±3．57）％。结论该方法测定阿苯达唑前体胶束包封率灵敏准确，重复性好，可以用于阿苯达唑前体胶束的包封率的测定。
目的：建立阿苯達唑前體膠束的包封率的測定方法。方法採用葡聚糖凝膠過濾法分離阿苯達唑膠束與遊離藥物，HPLC 法測定阿苯達唑前體膠束的包封率。結果 HPLC 法測定阿苯達唑前體膠束的包封率為76．38％～81．0％，RSD＝6．81％，迴收率為（92．23±3．57）％。結論該方法測定阿苯達唑前體膠束包封率靈敏準確，重複性好，可以用于阿苯達唑前體膠束的包封率的測定。
목적：건립아분체서전체효속적포봉솔적측정방법。방법채용포취당응효과려법분리아분체서효속여유리약물，HPLC 법측정아분체서전체효속적포봉솔。결과 HPLC 법측정아분체서전체효속적포봉솔위76．38％～81．0％，RSD＝6．81％，회수솔위（92．23±3．57）％。결론해방법측정아분체서전체효속포봉솔령민준학，중복성호，가이용우아분체서전체효속적포봉솔적측정。
Objective To develop a method for the determination of the drug entrapment efficiency of pre-micelle albendazole.Methods Use sephadex column to separate micelle encapsulated albendazole and free albendazole,and determination of the drug entrapment efficiency of premicelle albendazole by HPLC.Re-sults The drug entrapment efficiency of premicelle albendazole was 67-81% by HPLC and the average recovery was (92.23±3.57)%.Conclusion This method is sensitive,accurate,reproducible and suitable for the determination of the drug entrapment efficiency of premicelle albendazole .
